Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Stanford, CA, 94305, USA.
Curr Cardiol Rep. 2021 Jul 1;23(8):103. doi: 10.1007/s11886-021-01536-w.
Recent technological advances have led to an increased ability to define the gene expression profile of the cardiac conduction system (CCS). Here, we review the most salient studies to emerge in recent years and discuss existing gaps in our knowledge as well as future areas of investigation.
Molecular profiling of the CCS spans several decades. However, the advent of high-throughput sequencing strategies has allowed for the discovery of unique transcriptional programs of the many diverse CCS cell types. The CCS, a diverse structure with significant inter- and intra-component cellular heterogeneity, is essential to the normal function of the heart. Progress in transcriptomic profiling has improved the resolution and depth of characterization of these unique and clinically relevant CCS cell types. Future studies leveraging this big data will play a crucial role in improving our understanding of CCS development and function as well as translating these findings into tangible translational tools for the improved detection, prevention, and treatment of cardiac arrhythmias.
近年来，技术的进步使得人们能够更精确地定义心脏传导系统（CCS）的基因表达谱。在此，我们对近年来出现的最相关研究进行综述，并讨论我们现有知识的空白以及未来的研究领域。
对 CCS 的分子谱分析已经有几十年的历史了。然而，高通量测序策略的出现使得人们能够发现许多不同的 CCS 细胞类型独特的转录程序。CCS 是一个具有显著的细胞间和细胞内异质性的多样化结构，对心脏的正常功能至关重要。转录组谱分析的进展提高了对这些独特的、具有临床相关性的 CCS 细胞类型的特征描述的分辨率和深度。未来利用这些大数据的研究将在提高我们对 CCS 发育和功能的理解以及将这些发现转化为可用于提高心脏心律失常检测、预防和治疗的切实可行的转化工具方面发挥关键作用。
