Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Campus, Box 8100, St. Louis, MO, 63110, USA.
Department of Breast Surgery, First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Breast Cancer Res Treat. 2021 Sep;189(2):585-592. doi: 10.1007/s10549-021-06321-5. Epub 2021 Jul 1.
A dense breast on mammogram is a strong risk factor for breast cancer. Identifying factors that reduce mammographic breast density could thus provide insight into breast cancer prevention. Due to the limited number of studies and conflicting findings, we investigated the associations of medication use (specifically statins, aspirin, and ibuprofen) with mammographic breast density.
We evaluated these associations in 775 women who were recruited during an annual screening mammogram at Washington University School of Medicine, St. Louis. We measured mammographic breast density using Volpara. We used multivariable-adjusted linear regressions to determine the associations of medication use (statins, aspirin, and ibuprofen) with mammographic breast density. Least squared means were generated and back-transformed for easier interpretation.
The mean age of study participants was 52.9 years. Statin use in the prior 12 months was not associated with volumetric percent density or dense volume, but was positively associated with non-dense volume. The mean volumetric percent density was 8.6% among statin non-users, 7.2% among women who used statins 1-3 days/week, and 7.3% among women who used statins ≥ 4 days/week (p trend = 0.07). The non-dense volume was 1297.1 cm among statin non-users, 1368.7 cm among women who used statins 1-3 days/week, and 1408.4 cm among those who used statins ≥ 4 days/week (p trend = 0.02). We did not observe statistically significant differences in mammographic breast density by aspirin or ibuprofen use.
Statin, aspirin, and ibuprofen use was not associated with volumetric percent density and dense volume, but statin use was positively associated with non-dense volume. Any potential associations of these medications with breast cancer risk are unlikely to be mediated through an effect on volumetric percent density.
乳房 X 光片中致密的乳房是乳腺癌的一个强烈危险因素。因此，确定降低乳房 X 光片乳房密度的因素可以深入了解乳腺癌的预防。由于研究数量有限且结果相互矛盾，我们研究了药物使用（特别是他汀类药物、阿司匹林和布洛芬）与乳房 X 光片乳房密度的关系。
我们在圣路易斯华盛顿大学医学院进行年度筛查乳房 X 光检查期间招募了 775 名女性，对这些关联进行了评估。我们使用 Volpara 来测量乳房 X 光片乳房密度。我们使用多变量调整的线性回归来确定药物使用（他汀类药物、阿司匹林和布洛芬）与乳房 X 光片乳房密度的关系。生成最小二乘均值并进行反变换以方便解释。
研究参与者的平均年龄为 52.9 岁。在过去的 12 个月中使用他汀类药物与体积百分比密度或致密体积无关，但与非致密体积呈正相关。他汀类药物非使用者的平均体积百分比密度为 8.6%，每周使用他汀类药物 1-3 天的女性为 7.2%，每周使用他汀类药物≥4 天的女性为 7.3%（趋势检验=0.07）。他汀类药物非使用者的非致密体积为 1297.1cm，每周使用他汀类药物 1-3 天的女性为 1368.7cm，每周使用他汀类药物≥4 天的女性为 1408.4cm（趋势检验=0.02）。我们没有观察到阿司匹林或布洛芬使用与乳房 X 光片乳房密度有统计学显著差异。
他汀类药物、阿司匹林和布洛芬的使用与体积百分比密度和致密体积无关，但他汀类药物的使用与非致密体积呈正相关。这些药物与乳腺癌风险的任何潜在关联都不太可能通过对体积百分比密度的影响来介导。
