先天性巨细胞病毒（CMV）与儿科耳鼻喉科医师。

Congenital cytomegalovirus (CMV) for the pediatric otolaryngologist.

机构信息

Division of Pediatric Otolaryngology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Division of Pediatric Otolaryngology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA; Division of Otology and Neurotology, Head and Neck Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.

出版信息

Int J Pediatr Otorhinolaryngol. 2021 Sep;148:110809. doi: 10.1016/j.ijporl.2021.110809. Epub 2021 Jun 24.

DOI:10.1016/j.ijporl.2021.110809

PMID:34198225

Abstract

Cytomegalovirus (CMV) is a double-stranded DNA virus and a member of the herpesvirus family. It is the most common congenital viral infection. For symptomatic infections, symptoms can vary widely but tends to have a predilection for the central nervous system and for the reticuloendothelial system. Sensorineural hearing loss (SNHL) is by far the most common sequelae of congenital CMV infection. For this reason, it is imperative to understand the screening, diagnosis, and possible treatment options for congenital CMV induced SNHL. This literature review explores the association of CMV with hearing loss, screening for congenital CMV infections, possible treatments options, and the development of a possible vaccine.

摘要

巨细胞病毒（CMV）是一种双链 DNA 病毒，属于疱疹病毒科。它是最常见的先天性病毒感染。对于有症状的感染，症状可能差异很大，但往往偏爱中枢神经系统和网状内皮系统。感觉神经性听力损失（SNHL）是迄今为止先天性 CMV 感染最常见的后遗症。因此，了解先天性 CMV 诱导的 SNHL 的筛查、诊断和可能的治疗选择是至关重要的。本文献综述探讨了 CMV 与听力损失的关系、先天性 CMV 感染的筛查、可能的治疗选择以及可能的疫苗的开发。