接种mRNA疫苗后产生的抗体水平；既往感染SARS-CoV-2的影响。
Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2.
作者信息
Konstantinidis Theocharis G, Zisaki Stavroula, Mitroulis Ioannis, Konstantinidou Eleni, Kontekaki Eftychia G, Romanidou Gioulia, Karvelas Alexandros, Nanousi Ioanna, Lazidis Leonidas, Cassimos Dimitrios, Tsigalou Christina, Martinis Georges, Panopoulou Maria
机构信息
Blood Transfusion Center, University General Hospital of Alexandroupolis Dragana Campus, 68100 Alexandroupolis, Greece.
Laboratory of Microbiology, Democritus University of Thrace, University General Hospital of Alexandroupolis Dragana Campus, 68100 Alexandroupolis, Greece.
出版信息
J Clin Med. 2021 Jun 27;10(13):2842. doi: 10.3390/jcm10132842.
The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer of anti-Spike antibodies was 19,319.2 ± 1787.5 AU/mL. Vaccination induced a robust immunogenic response in those previously infected with SARS-CoV-2 compared with non-infected subjects. Additionally, individuals that were asymptomatic after vaccination produced lower levels of antibodies compared to feverish individuals. In conclusion, remarkably high levels of anti-Spike COVID-19 antibodies were observed after vaccination.
本研究的目的是评估针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的信使核糖核酸（mRNA）疫苗的免疫原性作用。本研究纳入了510名接种mRNA疫苗的参与者。使用雅培SARS-CoV-2免疫球蛋白G（IgG）定量检测法（雅培公司）进行抗2019冠状病毒病（COVID-19）抗体检测。总体而言，抗刺突抗体的平均滴度为19319.2±1787.5 AU/mL。与未感染的受试者相比，接种疫苗在既往感染过SARS-CoV-2的人群中诱导了强烈的免疫原性反应。此外，接种疫苗后无症状的个体产生的抗体水平低于发热个体。总之，接种疫苗后观察到抗COVID-19刺突抗体水平显著升高。
Zotero 插件