Šošo Daniela, Aljinović Jure, Lovrić Kojundžić Sanja, Marinović Ivanka, Čečuk Jeličić Esma, Marasović Krstulović Daniela
Department of Rehabilitation Medicine and Rheumatology, University Hospital Centre Split, 21 000 Split, Croatia.
Department of Health Studies, University of Split, 21 000 Split, Croatia.
Life (Basel). 2021 Jun 4;11(6):524. doi: 10.3390/life11060524.
We aimed to investigate possible association between the allele and peripheral arthritis, tenosynovitis and enthesitis.
Ultrasound of peripheral joints and tendons was performed in 72 positive patients with preliminary diagnosis of undifferentiated axial form of spondyloarthitis and joint and tendon pain. Patients with other known types of axial and peripheral spondyloarthritis were excluded as well as patients with other known types of arthritis.
Pathological changes were found in the joints of 33 (46%) patients and on the tendons in 13 (18%) patients. The most common ultrasound findings were joint effusion and synovial proliferation with positive power Doppler signal grade 1. The most common ultrasound finding in patients with painful tendons was tenosynovitis. A higher disease activity and an increased incidence of elevated CRP (≥5 mg/L) were more often observed in the group with positive ultrasound findings.
In this study, we showed that the allele could be a potential risk factor for developing peripheral arthritis, but not for tenosynovits and enthesitis in patients with the undifferentiated axial form of spondyloarthritis. This result may influence the follow up of these patients, especially since it gives us an opportunity to consider the use of different types of DMARDs in the treatment of these patients.
我们旨在研究[具体等位基因]与外周关节炎、腱鞘炎和附着点炎之间可能存在的关联。
对72例初步诊断为未分化轴向型脊柱关节炎且有关节和肌腱疼痛的[具体等位基因]阳性患者进行外周关节和肌腱的超声检查。排除其他已知类型的轴向和外周脊柱关节炎患者以及其他已知类型关节炎患者。
33例（46%）患者的关节及13例（18%）患者的肌腱发现病理改变。最常见的超声表现为关节积液和滑膜增生，能量多普勒信号为1级阳性。肌腱疼痛患者最常见的超声表现为腱鞘炎。超声检查结果阳性组更常观察到更高的疾病活动度和更高的CRP升高（≥5mg/L）发生率。
在本研究中，我们表明[具体等位基因]可能是未分化轴向型脊柱关节炎患者发生外周关节炎的潜在危险因素，但不是腱鞘炎和附着点炎的潜在危险因素。这一结果可能会影响这些患者的随访，特别是因为它使我们有机会考虑在这些患者的治疗中使用不同类型的改善病情抗风湿药。
