HLA-B*27 亚型及其在强直性脊柱炎发病机制中的意义。

HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis.

机构信息

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, TehranUniversity of Medical Sciences, Tehran, Iran.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Gene. 2018 Sep 5;670:15-21. doi: 10.1016/j.gene.2018.05.092. Epub 2018 May 24.

DOI:10.1016/j.gene.2018.05.092

PMID:29803000

Abstract

Ankylosing spondylitis (AS) is a highly heritable kind of arthritis that affects the vertebral column. AS risk has been associated strongly with Human leukocyte antigen (HLA)-B27. In fact, some HLA-B27 subtypes have been associated with the increased disease risk, although some specific subtypes have not shown such associations. It is supposed that HLA-B27 plays a major role in the etiopathogenesis of the disease. However, the difference in pathogenic outcomes of HLA-B27 certain subtypes needs to be clarified. The purpose of this review article is to overview on the detailed implications of the HLA-B27 subtypes in the etiopathogenesis of AS. Moreover, the role of ERAP1 in AS and its epistasis with HLA-B27 have been reviewed.

摘要

强直性脊柱炎（AS）是一种高度遗传性关节炎，主要影响脊柱。AS 风险与人类白细胞抗原（HLA）-B27 强烈相关。事实上，一些 HLA-B27 亚型与疾病风险增加有关，尽管一些特定亚型没有显示出这种关联。据推测，HLA-B27 在疾病的发病机制中起主要作用。然而，需要阐明 HLA-B27 某些亚型的致病结果的差异。本文综述了 HLA-B27 亚型在 AS 发病机制中的详细意义。此外，还综述了 ERAP1 在 AS 中的作用及其与 HLA-B27 的上位性。