Remmele W, Beck K, Kaiserling E
Institut für Pathologie, Klinikum der Landeshauptstadt, Wiesbaden, F.R.G.
Pathol Res Pract. 1988 Jun;183(3):336-46. doi: 10.1016/S0344-0338(88)80132-8.
Light and electron microscopic findings in a case of multiple lipid islands of the sigmoid mucosa are described. The patient apparently represents the second case with these lesions published in the medical literature. Lipid droplets were found in histiocytes, pericytes, smooth muscle cells, and Schwann cells. Pathological alterations of the nervous system in lipid islands have not been described before. The accumulation of lipids in different cell types of the colonic mucosa and the alterations of nervous elements are probably due to toxic factors reaching the cells either from the intestinal lumen or from the blood stream. The term "lipid proctitis (colitis)" does not appear to be useful because the lipid islands are obviously no disease sui generis but an epiphenomenon of other pathological processes. Pathological differential diagnosis and clinico-pathological correlation of colorectal lipid islands are briefly discussed.
本文描述了一例乙状结肠黏膜多发性脂质岛的光镜和电镜检查结果。该患者显然是医学文献中报道的第二例有这些病变的病例。在组织细胞、周细胞、平滑肌细胞和施万细胞中发现了脂滴。脂质岛中神经系统的病理改变此前尚未见报道。结肠黏膜不同细胞类型中脂质的积累以及神经成分的改变可能是由于有毒物质从肠腔或血流进入细胞所致。“脂质直肠炎（结肠炎）”这一术语似乎并无用处，因为脂质岛显然并非一种独特的疾病，而是其他病理过程的一种附带现象。本文简要讨论了结直肠脂质岛的病理鉴别诊断及临床病理相关性。
