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开发一种有前途的方法来生产支化亚烷基胍的低聚混合物，以提高物质质量，并评估其对 SARS-CoV-2 的抗病毒活性。

Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2.

机构信息

Institute of Fine Chemical Technologies Named after Lomonosov, MIREA-Russian Technological University, 119571 Moscow, Russia.

Institute of Pharmaceutical Technology, 119571 Moscow, Russia.

出版信息

Molecules. 2021 Jun 7;26(11):3472. doi: 10.3390/molecules26113472.

DOI:10.3390/molecules26113472
PMID:34200418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8201297/
Abstract

This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable method. Furthermore, the use of microfluidics allows the attainment of high-purity products with a low residual monomer content, which can expand the range of applications of this class of compounds. For all the samples obtained, the molecular-weight characteristics are calculated, based on which the optimal condensation conditions are established. Additionally, in this work, the antiviral activity of the alkylene guanidine salt against the SARS-CoV-2 virus is confirmed.

摘要

本文报道了使用微流控技术合成支化亚烷基胍。我们描述了在较低温度下制备胍衍生物的方法，所需时间明显短于以前适用方法所需的时间。此外，微流控技术的使用可以获得高纯度、残留单体含量低的产品，从而扩大这类化合物的应用范围。对于获得的所有样品，根据分子量特征计算，确定了最佳的缩合条件。此外，在这项工作中，还证实了亚烷基胍盐对 SARS-CoV-2 病毒的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/b8f733caea6f/molecules-26-03472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/0cb9b7bb48de/molecules-26-03472-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/a96a301a3b9b/molecules-26-03472-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/e799964ba5c7/molecules-26-03472-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/d997d5b1f30e/molecules-26-03472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/b8f733caea6f/molecules-26-03472-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/0cb9b7bb48de/molecules-26-03472-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/f72ec62337aa/molecules-26-03472-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/a96a301a3b9b/molecules-26-03472-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/e799964ba5c7/molecules-26-03472-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/d997d5b1f30e/molecules-26-03472-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/739d/8201297/b8f733caea6f/molecules-26-03472-g006.jpg

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