Yao Xingjun, Wen Sanmiao, Ji Ningning, Deng Qiulin, Li Zhiliang, Wang Hongbing, Shang Qianqian
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
College of Chemistry and Chemical Engineering, Taishan University, Tai'an 271021, China.
Molecules. 2024 Dec 26;30(1):41. doi: 10.3390/molecules30010041.
Hydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance the proton exchange rate, thereby boosting battery performance. This paper reviews recent advancements in the continuous synthesis of HOF synthons, in the continuous synthesis of HOF's unit small molecules enabling the multi-step, rapid, and in situ synthesis of synthons, such as carboxylic acid, diaminotriazine (DAT), urea, guanidine, imidazole, pyrazole, pyridine, thiazole, triazole, and tetrazole, with online monitoring. Continuous flow reactors facilitate fast chemical reactions and precise microfluidic control, offering superior reaction speed, product yield, and selectivity compared to batch processes. Integrating the continuous synthesis of synthons with the construction of HOF materials on a single platform is essential for achieving low-cost, safe, and efficient processing, especially for reactions involving toxic, flammable, or explosive substances.
氢键有机框架（HOF）材料通常由带有特定官能团的小有机单元（合成子）通过氢键或其他相互作用自组装而成。HOF通常用作电池的电解质。精心设计的HOF材料可以提高质子交换速率，从而提升电池性能。本文综述了HOF合成子连续合成方面的最新进展，即在HOF单元小分子的连续合成中，实现诸如羧酸、二氨基三嗪（DAT）、尿素、胍、咪唑、吡唑、吡啶、噻唑、三唑和四唑等合成子的多步、快速和原位合成，并进行在线监测。连续流动反应器有助于快速化学反应和精确的微流体控制，与间歇过程相比，具有更高的反应速度、产物收率和选择性。将合成子的连续合成与在单一平台上构建HOF材料相结合，对于实现低成本、安全和高效的加工至关重要，特别是对于涉及有毒、易燃或易爆物质的反应。
