Crankshaw Daune L, Briggs Jacquie E, Vince Robert, Nagasawa Herbert T
Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA.
Antioxidants (Basel). 2021 Jun 10;10(6):939. doi: 10.3390/antiox10060939.
L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.
L-半胱氨酸-谷胱甘肽混合二硫化物（CySSG）是谷胱甘肽（GSH）的前药，已发现其在小鼠中具有口服生物利用度，并能保护小鼠免受毒性剂量对乙酰氨基酚的伤害。如果在人体中也能证明其口服生物利用度，那么可以预想CySSG具有广泛的适用性。
