一种谷胱甘肽的口服生物可利用（小鼠）前药。
An Orally Bioavailable (Mice) Prodrug of Glutathione.
作者信息
Crankshaw Daune L, Briggs Jacquie E, Vince Robert, Nagasawa Herbert T
机构信息
Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA.
出版信息
Antioxidants (Basel). 2021 Jun 10;10(6):939. doi: 10.3390/antiox10060939.
Abstract
L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned.
摘要
L-半胱氨酸-谷胱甘肽混合二硫化物（CySSG）是谷胱甘肽（GSH）的前药，已发现其在小鼠中具有口服生物利用度，并能保护小鼠免受毒性剂量对乙酰氨基酚的伤害。如果在人体中也能证明其口服生物利用度，那么可以预想CySSG具有广泛的适用性。
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