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开放胰十二指肠切除术后新型仅经背部切口内翻式胰胃吻合术(Charité-PG)的开发——单中心经验

Development of a Novel Dorsal Incision Only Invagination Type Pancreatogastrostomy (Charité-PG) Following Open Pancreaticoduodenectomy-A Single Centre Experience.

作者信息

Timmermann Lea, Bahra Marcus, Pratschke Johann, Malinka Thomas

机构信息

Department of Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 14195 Berlin, Germany.

Department of Oncological Upper Abdominal Surgery and Robotic- Krankenhaus Waldfriede, 14163 Berlin, Germany.

出版信息

J Clin Med. 2021 Jun 10;10(12):2573. doi: 10.3390/jcm10122573.

Abstract

The implementation of a pancreatico-enteric anastomosis following open single stage pancreaticoduodenectomy (PD) is still associated with the most threatening complications in modern pancreatic surgery, such as postoperative pancreatic fistula (POPF), postpancreatectomy haemorrhage (PPH), delayed gastric emptying (DGE), intraabdominal abscesses and related mortality. With this study, we introduce Charité-PG, a new dorsal incision only invagination type pancreatogastrostomy (dioPG) for the restoration of the pancreatic remnant following PD, and compare it to a PG requiring ventral gastrotomy (vgPG). A total of 49 consecutive patients, who underwent reconstruction via dioPG, and 92 consecutive patients, who underwent restoration via vgPG, were identified from our prospective database and further reviewed for perioperative parameters, complication rates, mortality and follow-up. The percentage of overall complications ( = 0.301), as well as the 30-day mortality rate ( = 0.725) and survival ( = 0.543), were comparable in both groups. The operation time in the dioPG group was significantly shorter ( = 0.04), and patients in this group developed substantially fewer rates of DGE ( = 0.036). We provide a feasible and safe technique for restoration following PD via our novel dioPG, causing fewer cases of DGE. Nevertheless, pancreatico-enteric anastomoses require expertise and experience.

摘要

在开放性一期胰十二指肠切除术(PD)后实施胰肠吻合术,在现代胰腺手术中仍与最具威胁性的并发症相关,如术后胰瘘(POPF)、胰十二指肠切除术后出血(PPH)、胃排空延迟(DGE)、腹腔内脓肿及相关死亡率。通过本研究,我们引入了Charité-PG,一种仅通过背侧切口的内翻式胰胃吻合术(dioPG),用于PD术后胰腺残端的重建,并将其与需要腹侧胃切开术的胰胃吻合术(vgPG)进行比较。从我们的前瞻性数据库中识别出总共49例连续接受dioPG重建的患者和92例连续接受vgPG重建的患者,并进一步回顾其围手术期参数、并发症发生率、死亡率和随访情况。两组的总体并发症发生率(P = 0.301)、30天死亡率(P = 0.725)和生存率(P = 0.543)相当。dioPG组的手术时间明显更短(P = 0.04),且该组患者发生DGE的比率显著更低(P = 0.036)。我们通过新型dioPG为PD术后重建提供了一种可行且安全的技术,导致DGE病例更少。然而,胰肠吻合术需要专业知识和经验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8617/8230418/588032297ae5/jcm-10-02573-g001.jpg

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