• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

火龙果不同部位的抗氧化和抗炎植物化学物质及相关稳定顺磁性物质。

Antioxidative and Anti-Inflammatory Phytochemicals and Related Stable Paramagnetic Species in Different Parts of Dragon Fruit.

机构信息

Cluster of Excellence on Biodiversity-Based Economic and Society (B.BES-CMU), Chiang Mai University, Chiang Mai 50200, Thailand.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Molecules. 2021 Jun 10;26(12):3565. doi: 10.3390/molecules26123565.

DOI:10.3390/molecules26123565
PMID:34200974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8230633/
Abstract

In this study, we investigated the antioxidant and anti-inflammatory phytochemicals and paramagnetic species in dragon fruit using high-performance liquid chromatography (HPLC) and electron paramagnetic resonance (EPR). HPLC analysis demonstrated that dragon fruit is enriched with bioactive phytochemicals, with significant variations between each part of the fruit. Anthocyanins namely, cyanidin 3-glucoside, delphinidin 3-glucoside, and pelargonidin 3-glucoside were detected in the dragon fruit peel and fresh red pulp. Epicatechin gallate, epigallocatechin, caffeine, and gallic acid were found in the dragon fruit seed. Additionally, 25-100 mg × L of dragon fruit pulp and peel extracts containing enrichment of cyanidin 3-glucoside were found to inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in cell-based studies without exerted cytotoxicity. EPR primarily detected two paramagnetic species in the red samples. These two different radical species were assigned as stable radicals and Mn (paramagnetic species) based on the g-values and hyperfine components. In addition, the broad EPR line width of the white peel can be correlated to a unique moiety in dragon fruit. Our EPR and HPLC results provide new insight regarding the phytochemicals and related stable intermediates found in various parts of dragon fruit. Thus, we suggest here that there is the potential to use dragon fruit peel, which contains anthocyanins, as a natural active pharmaceutical ingredient.

摘要

在这项研究中，我们使用高效液相色谱（HPLC）和电子顺磁共振（EPR）研究了火龙果中的抗氧化和抗炎植物化学物质和顺磁物质。HPLC 分析表明，火龙果富含生物活性植物化学物质，其不同部位之间存在显著差异。在火龙果果皮和新鲜红色果肉中检测到花色苷，即矢车菊素 3-葡萄糖苷、飞燕草素 3-葡萄糖苷和天竺葵素 3-葡萄糖苷。此外，在火龙果种子中发现了表儿茶素没食子酸酯、表没食子儿茶素、咖啡因和没食子酸。此外，发现火龙果果肉和果皮提取物中含有 25-100mg×L 的矢车菊素 3-葡萄糖苷，可抑制细胞内活性氧（ROS）、活性氮（RNS）、诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的产生，而没有细胞毒性。EPR 主要在红色样品中检测到两种顺磁物质。这两种不同的自由基物种基于 g 值和超精细分量被分配为稳定自由基和 Mn（顺磁物种）。此外，白色果皮的宽 EPR 线宽可与火龙果中独特的部分相关。我们的 EPR 和 HPLC 结果为火龙果不同部位发现的植物化学物质和相关稳定中间体提供了新的见解。因此，我们建议在这里使用含有花色苷的火龙果果皮作为天然活性药物成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/7c74fc7cd44d/molecules-26-03565-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/e0e1091ec1c9/molecules-26-03565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/62163290c138/molecules-26-03565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/9379658dd053/molecules-26-03565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/e18d4a6cef56/molecules-26-03565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/245555a9f393/molecules-26-03565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/5d1f7770afb7/molecules-26-03565-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/0e7fe53190ae/molecules-26-03565-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/f2a875364500/molecules-26-03565-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/7c74fc7cd44d/molecules-26-03565-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/e0e1091ec1c9/molecules-26-03565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/62163290c138/molecules-26-03565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/9379658dd053/molecules-26-03565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/e18d4a6cef56/molecules-26-03565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/245555a9f393/molecules-26-03565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/5d1f7770afb7/molecules-26-03565-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/0e7fe53190ae/molecules-26-03565-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/f2a875364500/molecules-26-03565-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d8/8230633/7c74fc7cd44d/molecules-26-03565-g009.jpg

相似文献

1
Antioxidative and Anti-Inflammatory Phytochemicals and Related Stable Paramagnetic Species in Different Parts of Dragon Fruit.火龙果不同部位的抗氧化和抗炎植物化学物质及相关稳定顺磁性物质。
Molecules. 2021 Jun 10;26(12):3565. doi: 10.3390/molecules26123565.
2
Uncovering Potentially Therapeutic Phytochemicals, In silico Analysis, and Biological Assessment of South-Chinese Red Dragon Fruit (Hylocereus polyrhizus).揭示南火龙果（Hylocereus polyrhizus）中具有潜在治疗作用的植物化学物质：计算机分析与生物学评估。
Plant Foods Hum Nutr. 2024 Jun;79(2):474-481. doi: 10.1007/s11130-024-01151-4. Epub 2024 Feb 16.
3
Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits.草莓和黑莓果实中多酚提取物的抗炎和伤口愈合特性。
Food Res Int. 2019 Jul;121:453-462. doi: 10.1016/j.foodres.2018.11.059. Epub 2018 Nov 28.
4
Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity.采用 LC-ESI-QTOF-MS 对新型巴西超级水果中的生物活性酚进行综合表征，以及它们的 ROS 和 RNS 清除作用和抗炎活性。
Food Chem. 2019 May 30;281:178-188. doi: 10.1016/j.foodchem.2018.12.106. Epub 2019 Jan 3.
5
Comparative antioxidant and antiproliferative activities of red and white pitayas and their correlation with flavonoid and polyphenol content.火龙果的抗氧化和抗增殖活性比较及其与类黄酮和多酚含量的相关性。
J Food Sci. 2011 Jan-Feb;76(1):C38-45. doi: 10.1111/j.1750-3841.2010.01908.x. Epub 2010 Nov 29.
6
The impacts of peel inclusion and fermentation temperature on the bioactive compounds, antioxidant activity, and sensory properties of dragon fruit wines.果皮的加入和发酵温度对火龙果酒中生物活性化合物、抗氧化活性和感官特性的影响。
Acta Sci Pol Technol Aliment. 2021 Jul-Sep;20(3):337-346. doi: 10.17306/J.AFS.0907.
7
Investigating Pigment Radicals in Black Rice Using HPLC and Multi-EPR.利用高效液相色谱法（HPLC）和多电子顺磁共振（Multi-EPR）研究黑米中的色素自由基
J Oleo Sci. 2017;66(5):543-547. doi: 10.5650/jos.ess16245.
8
Detection of Antioxidant Phytochemicals Isolated from Seeds Using HPLC and EPR Imaging.使用高效液相色谱法（HPLC）和电子顺磁共振成像（EPR）检测从种子中分离出的抗氧化植物化学物质。
Antioxidants (Basel). 2020 Jun 5;9(6):493. doi: 10.3390/antiox9060493.
9
Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells.红桑皮提取物对 HepG2 人肝癌细胞表现出抗增殖活性。
Food Res Int. 2019 Oct;124:93-100. doi: 10.1016/j.foodres.2018.08.040. Epub 2018 Aug 20.
10
EPR imaging and HPLC characterization of the pigment-based organic free radical in black soybean seeds.黑豆种子中基于色素的有机自由基的电子顺磁共振成像和高效液相色谱表征
Free Radic Res. 2017 Feb;51(2):187-192. doi: 10.1080/10715762.2017.1291940.

引用本文的文献

1
Enhancement of nutritional and flavor properties of red-fleshed pitaya juice via fermentation.通过发酵提高红肉火龙果果汁的营养和风味特性
Food Chem X. 2025 Aug 13;30:102915. doi: 10.1016/j.fochx.2025.102915. eCollection 2025 Aug.
2
Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways.来自泰国北部种植的一种新型杂交甘薯皮的花青素通过调节活性氧介导的途径减轻脂多糖诱导的炎症和核因子κB受体活化因子配体诱导的骨质疏松症。
Inflammopharmacology. 2025 Jan;33(1):381-399. doi: 10.1007/s10787-024-01634-5. Epub 2025 Jan 13.
3

本文引用的文献

1
Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties.火龙果作为具有化学预防特性的天然多酚的蕴藏库。
Molecules. 2021 Apr 9;26(8):2158. doi: 10.3390/molecules26082158.
2
Anthocyanin Structure and pH Dependent Extraction Characteristics from Blueberries () and Chokeberries () in Subcritical Water State.亚临界水状态下蓝莓（）和黑 chokeberry（）中花色苷的结构及pH依赖性提取特性
Foods. 2021 Mar 3;10(3):527. doi: 10.3390/foods10030527.
3
Biochemical and nutritional characterization of dragon fruit (Hylocereus species).
Nutritional Value and Therapeutic Benefits of Dragon Fruit: A Comprehensive Review with Implications for Establishing Australian Industry Standards.
火龙果的营养价值与治疗功效：一项对制定澳大利亚行业标准有启示意义的综合综述
Molecules. 2024 Nov 30;29(23):5676. doi: 10.3390/molecules29235676.
4
Pitahaya ()-Peel and -Flesh Flour Obtained from Fruit Co-Products-Assessment of Chemical, Techno-Functional and In Vitro Antioxidant Properties.火龙果（）-果皮-果肉粉的制取-水果副产物的评估-化学、技术功能和体外抗氧化性能。
Molecules. 2024 May 10;29(10):2241. doi: 10.3390/molecules29102241.
5
Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds.火龙果的抗炎、抗氧化及其他健康功效及其生物活性化合物的潜在递送系统
Pharmaceutics. 2023 Jan 3;15(1):159. doi: 10.3390/pharmaceutics15010159.
6
Betacyanins and Anthocyanins in Pulp and Peel of Red Pitaya ( cv. Jindu), Inhibition of Oxidative Stress, Lipid Reducing, and Cytotoxic Effects.红肉火龙果（品种：金都）果肉和果皮中的甜菜色素和花色苷：对氧化应激的抑制、降脂及细胞毒性作用
Front Nutr. 2022 Jun 23;9:894438. doi: 10.3389/fnut.2022.894438. eCollection 2022.
7
Development of a Sericin Hydrogel to Deliver Anthocyanins from Purple Waxy Corn Cob ( L.) Extract and In Vitro Evaluation of Anti-Inflammatory Effects.用于递送紫糯玉米芯提取物中花色苷的丝胶蛋白水凝胶的研制及抗炎作用的体外评价
Pharmaceutics. 2022 Mar 6;14(3):577. doi: 10.3390/pharmaceutics14030577.
8
Maturation Process, Nutritional Profile, Bioactivities and Utilisation in Food Products of Red Pitaya Fruits: A Review.红肉火龙果果实的成熟过程、营养成分、生物活性及其在食品中的应用：综述
Foods. 2021 Nov 18;10(11):2862. doi: 10.3390/foods10112862.
9
A Simple Minimized System Based on Moving Drops for Antioxidant Analysis Using a Smartphone.基于移动液滴的简易化系统，用于智能手机的抗氧化分析。
Molecules. 2021 Sep 22;26(19):5744. doi: 10.3390/molecules26195744.
10
Anthocyanin Profile, Antioxidant, Anti-Inflammatory, and Antimicrobial against Foodborne Pathogens Activities of Purple Rice Cultivars in Northern Thailand.泰国北部紫米品种花色苷组成、抗氧化、抗炎和抗食源性病原体活性的研究。
Molecules. 2021 Aug 29;26(17):5234. doi: 10.3390/molecules26175234.
火龙果（Hylocereus 种）的生化和营养特性。
Food Chem. 2021 Aug 15;353:129426. doi: 10.1016/j.foodchem.2021.129426. Epub 2021 Mar 3.
4
The Health Benefits of Dietary Fibre.膳食纤维的健康益处。
Nutrients. 2020 Oct 21;12(10):3209. doi: 10.3390/nu12103209.
5
Maillard Reaction Intermediates and Related Phytochemicals in Black Garlic Determined by EPR and HPLC Analyses.通过电子顺磁共振波谱（EPR）和高效液相色谱（HPLC）分析确定黑蒜中的美拉德反应中间体及相关植物化学物质。
Molecules. 2020 Oct 7;25(19):4578. doi: 10.3390/molecules25194578.
6
Contribution of anthocyanin pathways to fruit flesh coloration in pitayas.花色苷途径对火龙果果肉颜色的贡献。
BMC Plant Biol. 2020 Jul 31;20(1):361. doi: 10.1186/s12870-020-02566-2.
7
Health effects of vitamin and mineral supplements.维生素和矿物质补充剂的健康影响。
BMJ. 2020 Jun 29;369:m2511. doi: 10.1136/bmj.m2511.
8
Detection of Antioxidant Phytochemicals Isolated from Seeds Using HPLC and EPR Imaging.使用高效液相色谱法（HPLC）和电子顺磁共振成像（EPR）检测从种子中分离出的抗氧化植物化学物质。
Antioxidants (Basel). 2020 Jun 5;9(6):493. doi: 10.3390/antiox9060493.
9
Phenolic Acids of Plant Origin-A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties.植物源酚酸——关于其体外（油/水乳液体系）抗氧化活性及其体内健康生化特性的综述
Foods. 2020 Apr 24;9(4):534. doi: 10.3390/foods9040534.
10
Glycolytic genes expression, proapoptotic potential in relation to the total content of bioactive compounds in durian fruits.榴梿果实中糖酵解基因表达与生物活性化合物总量的关系及其促凋亡潜能。
Food Res Int. 2019 Nov;125:108563. doi: 10.1016/j.foodres.2019.108563. Epub 2019 Jul 15.