采用 LC-ESI-QTOF-MS 对新型巴西超级水果中的生物活性酚进行综合表征，以及它们的 ROS 和 RNS 清除作用和抗炎活性。
Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity.
机构信息
Department of Agri-Food Industry, Food and Nutrition, "Luiz de Queiroz" College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900 Piracicaba, SP, Brazil.
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, 901 Limeira, 901 Ave, Areião, 13414-018 Piracicaba, SP, Brazil.
出版信息
Food Chem. 2019 May 30;281:178-188. doi: 10.1016/j.foodchem.2018.12.106. Epub 2019 Jan 3.
Brazilian native fruits (BNF) remain unexplored and underutilized resources with a high potential to improve human health and wellness. In our study, five new BNF (Eugenia stipitata, Sageretia elegans, Byrsonima arthropoda, Spondias mombin andRubus rosaefolius)were evaluated for their phenolic composition by LC-ESI-QTOF-MS; and for their ROS and RNS scavenging effects (ROO, O, NO, HOCl); in vivo anti-inflammatory activity (neutrophil migration); and in vivo acute toxicity in Galleria mellonella. Eighty-six phenolic compounds were identified, including hydroxybenzoic acids, hydroxycinnamic acids, flavonoids, anthocyanins and ellagitannins, several of which had never been reported in BNF. The BNF exhibited high antioxidant effects against biologically relevant radicals, and treated animals showed decreased neutrophil influx and NF-kB activation. Thus, these BNF are good sources of antioxidant and anti-inflammatory molecules that can be beneficial for human health as functional foods. Based on their bioactivity, they can be considered as new Brazilian superfruits.
巴西本土水果（BNF）是未被充分开发和利用的资源，具有提高人类健康和福祉的巨大潜力。在我们的研究中，五种新的 BNF（Eugenia stipitata、Sageretia elegans、Byrsonima arthropoda、Spondias mombin 和 Rubus rosaefolius）通过 LC-ESI-QTOF-MS 评估了其酚类成分；并评估了它们的 ROS 和 RNS 清除作用（ROO、O、NO、HOCl）；体内抗炎活性（中性粒细胞迁移）；以及在 Galleria mellonella 中的体内急性毒性。鉴定了 86 种酚类化合物，包括羟基苯甲酸、羟基肉桂酸、类黄酮、花青素和鞣花单宁，其中一些从未在 BNF 中报道过。BNF 对生物相关自由基表现出高抗氧化作用，并且处理过的动物显示出中性粒细胞流入和 NF-kB 激活减少。因此，这些 BNF 是抗氧化和抗炎分子的良好来源，可作为功能性食品有益于人类健康。基于它们的生物活性，可以将它们视为新的巴西超级水果。
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