Yanardag Sila, Pugacheva Elena N
Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
West Virginia University Cancer Institute, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Cells. 2021 Jun 8;10(6):1428. doi: 10.3390/cells10061428.
Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance. All stem cells characterized so far have primary cilia. They serve as entry- or check-points for various signaling events by controlling the signal transduction and stability. Thus, defects in the primary cilia formation or dynamics cause developmental and health problems, including but not limited to obesity, cardiovascular and renal anomalies, hearing and vision loss, and even cancers. In this review, we focus on the recent findings of how primary cilium controls various signaling pathways during stem cell differentiation and identify potential gaps in the field for future research.
信号网络在干细胞的谱系特化和终末分化过程中引导干细胞。初级纤毛是一种类似天线的突起，在这种引导过程中直接或间接地发挥着重要作用。迄今为止所鉴定的所有干细胞都有初级纤毛。它们通过控制信号转导和稳定性，充当各种信号事件的入口或检查点。因此，初级纤毛形成或动力学方面的缺陷会导致发育和健康问题，包括但不限于肥胖、心血管和肾脏异常、听力和视力丧失，甚至癌症。在本综述中，我们重点关注初级纤毛在干细胞分化过程中如何控制各种信号通路的最新研究发现，并确定该领域未来研究的潜在空白。
