Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, China.
Biomolecules. 2021 Jun 8;11(6):853. doi: 10.3390/biom11060853.
The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer.
先前已有研究报道肿瘤内胆固醇酯（CE）与肿瘤进展之间存在关联。本研究旨在探究 CE 对乳腺肿瘤进展的因果影响。我们使用 MMTV-PyMT（MMTV-多瘤病毒中 T）转基因小鼠和乳腺癌细胞 MCF-7 表明，外源性和内源性 CE 均可促进乳腺肿瘤生长，CE 上调 AKT/mTOR 通路，而 CE 合成阻断可抑制该信号通路。我们的数据表明，甾醇 O-酰基转移酶 SOAT1 可能是治疗乳腺癌的潜在靶点。
