Tu Teng, Zhang Hongying, Xu Huanji
Department of Medical Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Oncogene, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2023 Jun 20;13:1197502. doi: 10.3389/fonc.2023.1197502. eCollection 2023.
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1.
胆固醇酯化在癌症中常常失调。固醇O-酰基转移酶1（SOAT1）通过催化细胞内胆固醇与长链脂肪酸形成胆固醇酯，在维持细胞胆固醇稳态中发挥重要作用。许多研究表明，SOAT1在癌症的发生和发展中起着至关重要的作用，是新型抗癌治疗的一个有吸引力的靶点。在这篇综述中，我们概述了SOAT1在癌症中的作用机制和调控，并总结了针对SOAT1的抗癌治疗的进展。
