3-苯甲酰基异恶唑啉的 1,3-偶极环加成反应：氯胺-T 催化的α-硝基酮与偶极子的缩合反应。
3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles.
机构信息
Stake Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Key Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China.
出版信息
Molecules. 2021 Jun 8;26(12):3491. doi: 10.3390/molecules26123491.
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.
在这项研究中，通过用氯胺-T 作为碱，使烯烃与各种α-硝基酮反应来合成 3-苯甲酰异恶唑啉。α-硝基酮和烯烃的范围很广，包括不同的烯烃和炔烃，形成各种异恶唑啉和异恶唑。使用氯胺-T 作为廉价、易处理、适度的 1,3-偶极环加成的碱是有吸引力的。
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