通过化学和区域选择性的内分子腈氧化物环加成反应全合成（+）-波考宁 D 和（+）-单胞菌素 II。
Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition.
机构信息
Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology , Yuseong, Daejeon 34114, Republic of Korea.
University of Science and Technology , Daejeon 34114, Republic of Korea.
出版信息
Org Lett. 2017 Nov 3;19(21):6004-6007. doi: 10.1021/acs.orglett.7b03054.
PMID:29048170
Abstract
Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition of diene 4.
摘要
（+）-波考宁 D（1）和（+）-单胞菌素 II（2）的不对称全合成，具有很强的抗癌活性的 Hsp90 抑制剂，已经完成，其中大环内酯 3 通过二烯 4 的化学和区域选择性的分子内腈氧化物环加成反应构建。
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