Guarini S, Ferrari W, Bertolini A
Institute of Pharmacology, University of Modena, Italy.
Pharmacol Res Commun. 1988 May;20(5):395-403. doi: 10.1016/s0031-6989(88)80015-8.
Subtotally hepatectomized or sham-operated rats were bled to hypovolemic shock (mean arterial pressure = 18-25 mmHg) and then treated with an intravenous bolus injection of ACTH-(1-24), 160 ug/kg. The treatment caused a prompt and sustained reversal of hypotension, with survival of all sham-operated animals, at least for the first 2 h, while in hepatectomized rats the arterial pressure increase was negligible and there was a 50% mortality within 2 h after treatment. Moreover, the blood volume which could be drained from an arterial catheter prior to death, measured 15-20 min after ACTH injection, was 1.51 +/- 0.12 and 0.64 +/- 0.11 ml/100 g b.w. in sham-operated and hepatectomized rats, respectively. These results further support the idea that the effect of ACTH in haemorrhagic shock is due to the mobilization of blood pooled in peripheral reserve organs.
将大鼠进行次全肝切除或假手术，然后使其出血至低血容量性休克（平均动脉压 = 18 - 25 mmHg），接着静脉推注160 μg/kg的促肾上腺皮质激素（ACTH）-(1 - 24)进行治疗。该治疗迅速且持续地逆转了低血压，所有假手术动物均存活，至少在最初2小时内存活，而在肝切除大鼠中，动脉压升高可忽略不计，且治疗后2小时内死亡率为50%。此外，在注射ACTH后15 - 20分钟测量，假手术和肝切除大鼠在死亡前可从动脉导管引流的血量分别为1.51±0.12和0.64±0.11 ml/100 g体重。这些结果进一步支持了以下观点：ACTH在失血性休克中的作用是由于动员了外周储备器官中蓄积的血液。
