静脉注射CCK-8对失血性休克大鼠血液学变化的影响。

Haematological changes induced by the intravenous injection of CCK-8 in rats subjected to haemorrhagic shock.

作者信息

Guarini S, Bazzani C, Leo L, Bertolini A

机构信息

Institute of Pharmacology, University of Modena, Italy.

出版信息

Neuropeptides. 1988 Feb-Mar;11(2):69-72. doi: 10.1016/0143-4179(88)90012-1.

DOI:10.1016/0143-4179(88)90012-1

PMID:3368038

Abstract

In rats bled to invariably fatal haemorrhagic shock (mean arterial pressure = 18-24 mmHg), the prompt and sustained improvement of cardiovascular function, obtained with the i.v. injection of cholecystokinin octapeptide (CCK-8, 20 g/kg) is associated with a massive increase in the volume of residual circulating blood (0.69 +/- 0.12 ml/100 g b.w. in saline-treated rats; 1.61 +/- 0.09 ml/100 g b.w. in CCK-8-treated rats). The number of red cells/mm3 and the % Hb content is the same in CCK-8-treated and in control rats. So, in a condition of severe haemorrhage, otherwise incompatible with survival, the i.v. injection of CCK-8 not only induces an impressive increase in arterial pressure and in circulating blood volume, but also greatly improves tissue oxygenation.

摘要

在因出血性休克而濒死（平均动脉压 = 18 - 24 mmHg）的大鼠中，静脉注射八肽胆囊收缩素（CCK - 8，20 μg/kg）能迅速且持续地改善心血管功能，这与残余循环血量的大量增加有关（生理盐水处理组大鼠为0.69 ± 0.12 ml/100 g体重；CCK - 8处理组大鼠为1.61 ± 0.09 ml/100 g体重）。CCK - 8处理组大鼠和对照组大鼠的红细胞/mm³数量及血红蛋白含量百分比相同。因此，在严重出血且原本无法存活的情况下，静脉注射CCK - 8不仅能显著提高动脉压和循环血量，还能极大地改善组织氧合。