Towson University Herpes Virus Lab, Department of Biological Sciences, Towson University, Towson, MD 21252, USA.
Towson University Department of Chemistry, Towson, MD 21252, USA.
Viruses. 2021 Jun 25;13(7):1228. doi: 10.3390/v13071228.
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is imperative that we provide interventions to keep them at bay, especially in immunocompromised patients. While numerous experimental vaccines are under consideration, current intervention consists solely of antiviral chemotherapeutic agents. This review explores all of the clinically approved drugs used to prevent the worst sequelae of recurrent outbreaks by these viruses.
单纯疱疹病毒-1 和 -2（HSV-1 和 -2）是引起全球感染的三种人类α疱疹病毒中的两种。由于这两种病毒在没有明显迹象和症状的情况下也可以被感染，而且仍然会导致终身感染，因此我们必须采取干预措施来控制它们，尤其是在免疫功能低下的患者中。虽然有许多实验性疫苗正在考虑中，但目前的干预措施仅包括抗病毒化学治疗药物。这篇综述探讨了所有经临床批准用于预防这些病毒反复发作的最坏后果的药物。
