Mărgăoan Rodica, Topal Erkan, Balkanska Ralitsa, Yücel Banu, Oravecz Titanilla, Cornea-Cipcigan Mihaiela, Vodnar Dan Cristian
Advanced Horticultural Research Institute of Transylvania, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
Apiculture Research Center, Aegean Agricultural Research Institute, İzmir 35100, Turkey.
Antioxidants (Basel). 2021 Jun 25;10(7):1023. doi: 10.3390/antiox10071023.
vegetative diversity is based on different climate and geographical origins. In terms of beekeeping, herbal diversity is strongly correlated to the production of a wide variety of honey. Therefore, based on the existing plant diversity in each country, multiple honey varieties are produced with different health characteristics. While beekeeping potential and consumption preferences are reflected in products' variety, this leads to an increase in the region's economy and extensive export. In the last years, monofloral honey has gained interest from consumers and especially in the medicinal field due to the presence of phytochemicals which are directly linked to health benefits, wound healing, antioxidant, anticancer and anti-inflammatory activities. Scope and approach: this review aims to highlight the physicochemical properties, mineral profiles and antioxidant activities of selected monofloral honeys based on their botanical and geographical origin. Moreover, this review focuses on the intercorrelation between monofloral honey's antioxidant compounds and in vitro and in vivo activities, focusing on the apoptosis and cell proliferation inhibition in various cell lines, with a final usage of honey as a potential therapeutic product in the fight towards reducing tumor growth. Key findings and conclusions: multiple studies have demonstrated that monofloral honeys have different physicochemical structures and bioactive compounds. Useful chemical markers to distinguish between monofloral honeys were evidenced, such as: 2-methoxybenzoic acid and trimethoxybenzoic acid are distinctive to Manuka honey while 4-methoxyphenylacetic acid is characteristic to Kanuka honey. Furthermore, resveratrol, epigallocatechin and pinostrobin are markers distinct to Sage honey, whereas carvacrol and thymol are found in Ziziphus honey. Due to their polyphenolic profile, monofloral honeys have significant antioxidant activity, as well as antidiabetic, antimicrobial and anticancer activities. It was demonstrated that Pine honey decreased the MDA and TBARS levels in liver, kidney, heart and brain tissues, whereas Malicia honey reduced the low-density lipoprotein level. Consumption of Clover, Acacia and Gelam honeys reduced the weight and adiposity, as well as trygliceride levels. Furthermore, the antiproliferative effect of chrysin, a natural flavone in Acacia honey, was demonstrated in human (A375) and murine (B16-F1) melanoma cell lines, whereas caffeic acid, a phenolic compound found in Kelulut honey, proves to be significant candidate in the chemoprevention of colon cancer. Based on these features, the use of hiney in the medicinal field (apitherapy), and the widespread usage of natural product consumption, is gaining interest by each year.
植物多样性基于不同的气候和地理起源。就养蜂而言，植物多样性与多种蜂蜜的产量密切相关。因此，根据每个国家现有的植物多样性，生产出具有不同健康特性的多种蜂蜜品种。虽然养蜂潜力和消费偏好体现在产品的多样性上，但这会促进该地区经济增长并带来大量出口。近年来，单花蜂蜜受到消费者的青睐，尤其是在医药领域，因为其中存在与健康益处、伤口愈合、抗氧化、抗癌和抗炎活性直接相关的植物化学物质。范围和方法：本综述旨在突出所选单花蜂蜜基于其植物和地理起源的物理化学性质、矿物质成分和抗氧化活性。此外，本综述重点关注单花蜂蜜抗氧化化合物与体外和体内活性之间的相互关系，着重于各种细胞系中的细胞凋亡和细胞增殖抑制，最终将蜂蜜用作对抗肿瘤生长的潜在治疗产品。主要发现和结论：多项研究表明，单花蜂蜜具有不同的物理化学结构和生物活性化合物。已证实可用于区分单花蜂蜜的有用化学标志物，例如：2 - 甲氧基苯甲酸和三甲氧基苯甲酸是麦卢卡蜂蜜的特征性成分，而4 - 甲氧基苯乙酸是卡努卡蜂蜜的特征成分。此外，白藜芦醇、表没食子儿茶素和松属素是鼠尾草蜂蜜特有的标志物，而香芹酚和百里香酚存在于酸枣蜂蜜中。由于其多酚成分，单花蜂蜜具有显著的抗氧化活性，以及抗糖尿病、抗菌和抗癌活性。已证明松树蜂蜜可降低肝脏、肾脏、心脏和脑组织中的丙二醛（MDA）和硫代巴比妥酸反应物（TBARS）水平，而马利西亚蜂蜜可降低低密度脂蛋白水平。食用三叶草、刺槐和吉拉蒙蜂蜜可减轻体重和肥胖程度，并降低甘油三酯水平。此外，刺槐蜂蜜中的天然黄酮白杨素在人（A375）和鼠（B16 - F1）黑色素瘤细胞系中表现出抗增殖作用，而吉卢特蜂蜜中发现的酚类化合物咖啡酸被证明是结肠癌化学预防的重要候选物质。基于这些特性，蜂蜜在医药领域（蜂疗）的应用以及天然产品消费的广泛使用逐年受到关注。
