Lin Yen-Hung, Lee Sheng-I, Lin Feng-Huei, Wu Guan-Xuan, Wu Chun-Shien, Kuo Shyh-Ming
Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung City 82445, Taiwan.
Department of Pharmacy and Master Program, Tajen University, Yanpu Township 90741, Taiwan.
Pharmaceutics. 2021 Jun 24;13(7):944. doi: 10.3390/pharmaceutics13070944.
Most rotator cuff (RC) tears occur at the bone-tendon interface and cause disability and pain. Farnesol, a sesquiterpene compound, can exert antioxidative and anti-inflammatory effects and promote collagen synthesis. In this rabbit model, either commercial SurgiWrap membrane or hydrogel membranes containing various compositions of gellan gum, hyaluronic acid, and farnesol (hereafter GHF membranes) were applied to the tear site, and the repair of the cuff was examined 2 and 3 weeks afterward. The designed membranes swelled rapidly and adsorbed onto the tear site more readily and closely than the SurgiWrap membrane. The membranes degraded slowly and functioned as both a barrier and a vehicle of slow farnesol release during the repair period. Farnesol enhanced collagen production in myoblasts and tenocytes, and interleukin 6 and tumor necrosis factor α levels were modulated. Gross observations and histological examinations indicated that the GHF membranes impregnated with 4 mM farnesol resulted in superior RC repair. In sum, the slow release of farnesol from hydrogel membranes can be beneficial in the repair of RC injuries.
大多数肩袖（RC）撕裂发生在骨-肌腱界面，会导致功能障碍和疼痛。法尼醇是一种倍半萜化合物，具有抗氧化和抗炎作用，并能促进胶原蛋白合成。在这个兔子模型中，将商用SurgiWrap膜或含有结冷胶、透明质酸和法尼醇的各种组合物的水凝胶膜（以下简称GHF膜）应用于撕裂部位，并在2周和3周后检查袖带的修复情况。与SurgiWrap膜相比，设计的膜迅速膨胀，更容易且更紧密地吸附在撕裂部位。这些膜降解缓慢，在修复期间既起到屏障作用，又作为法尼醇缓慢释放的载体。法尼醇增强了成肌细胞和肌腱细胞中的胶原蛋白生成，并调节了白细胞介素6和肿瘤坏死因子α水平。大体观察和组织学检查表明，浸渍有4 mM法尼醇的GHF膜导致了更好的肩袖修复。总之，水凝胶膜中法尼醇的缓慢释放对肩袖损伤的修复可能有益。
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