Yamakawa Sho, Hayashida Kenji
Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501 Japan.
Burns Trauma. 2019 Apr 5;7:10. doi: 10.1186/s41038-019-0148-1. eCollection 2019.
Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation , allowing for external modulation of the healing process. Perioperative drug delivery systems can enhance the biological activity of these growth factors, which have a very short half-life after topical administration. Although the basic mechanisms of these growth factors are well understood, most have yet to demonstrate a significant impact in animal studies or small-sized clinical trials. In this review, we emphasized currently approved growth factor therapies, including a sustained release system for growth factors, emerging therapies, and future research possibilities combined with surgical procedures. Approaches seeking to understand wound healing at a systemic level are currently ongoing. However, further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.
生长因子最近在伤口处理方面具有了临床重要性。已证明应用重组生长因子可模拟细胞迁移、增殖和分化，从而实现对愈合过程的外部调节。围手术期给药系统可增强这些生长因子的生物活性，因为这些生长因子局部给药后的半衰期非常短。尽管对这些生长因子的基本机制已了解得很清楚，但大多数在动物研究或小型临床试验中尚未显示出显著影响。在本综述中，我们重点介绍了目前已获批准的生长因子疗法，包括生长因子的缓释系统、新兴疗法以及与外科手术相结合的未来研究可能性。目前正在进行从系统层面了解伤口愈合的研究。然而，还需要在外科领域进行进一步研究和思考，以明确证实生长因子疗法对难治性伤口的疗效。
