Kim Jong-Ho, Rhee Sung Min, Hwang Jung-Taek, Jo Chris Hyunchul
Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Orthopedic Surgery, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul, Korea.
Clin Shoulder Elb. 2025 Jun;28(2):223-241. doi: 10.5397/cise.2024.01053. Epub 2025 May 23.
Rotator cuff disease is a prevalent musculoskeletal condition associated with significant pain and functional impairment. Various injection therapies, ranging from corticosteroids to advanced biologic approaches, offer potential solutions for managing rotator cuff disease. This scoping review consolidates evidence on the efficacy, safety, and mechanisms of these treatments. Corticosteroid injections, while effective for short-term pain relief, pose risks of tendon degeneration with prolonged use. Platelet-rich plasma demonstrates promise in promoting tendon healing and improving long-term outcomes, but variability in preparation methods limits its clinical consistency. Hyaluronic acid and prolotherapy show potential in improving pain and tendon function, often serving as adjuncts in combined therapeutic strategies. Emerging regenerative options, such as polydeoxyribonucleotide and bone marrow aspirate concentrate, leverage growth factors and stem cells to enhance tendon repair and reduce degeneration, with preliminary evidence supporting their clinical efficacy. By synthesizing current knowledge on injection therapy for rotator cuff disease, this review provides valuable insights for clinicians and researchers seeking to enhance the management of rotator cuff disease through injection therapy.
肩袖疾病是一种常见的肌肉骨骼疾病，会导致严重疼痛和功能障碍。从皮质类固醇到先进的生物疗法等各种注射疗法，为肩袖疾病的治疗提供了潜在的解决方案。本综述整合了这些治疗方法的疗效、安全性及作用机制的证据。皮质类固醇注射虽然能有效缓解短期疼痛，但长期使用存在肌腱退变的风险。富血小板血浆在促进肌腱愈合和改善长期疗效方面显示出前景，但制备方法的差异限制了其临床应用的一致性。透明质酸和注射疗法在改善疼痛和肌腱功能方面具有潜力，常作为联合治疗策略的辅助手段。新兴的再生疗法，如聚脱氧核糖核苷酸和骨髓抽吸浓缩物，利用生长因子和干细胞来增强肌腱修复并减少退变，初步证据支持其临床疗效。通过综合当前关于肩袖疾病注射治疗的知识，本综述为寻求通过注射疗法加强肩袖疾病管理的临床医生和研究人员提供了有价值的见解。
