评估包膜细菌感染和疫苗接种后的功能性免疫
Evaluating Functional Immunity Following Encapsulated Bacterial Infection and Vaccination.
作者信息
Toh Zheng Quan, Higgins Rachel A, Mazarakis Nadia, Abbott Elysia, Nathanielsz Jordan, Balloch Anne, Mulholland Kim, Licciardi Paul V
机构信息
Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, VIC 3052, Australia.
出版信息
Vaccines (Basel). 2021 Jun 20;9(6):677. doi: 10.3390/vaccines9060677.
Encapsulated bacteria such as , type b and cause significant morbidity and mortality in young children despite the availability of vaccines. Highly specific antibodies are the primary mechanism of protection against invasive disease. Robust and standardised assays that measure functional antibodies are also necessary for vaccine evaluation and allow for the accurate comparison of data between clinical studies. This mini review describes the current state of functional antibody assays and their importance in measuring protective immunity.
尽管有疫苗可用，但如b型等包膜细菌在幼儿中仍会导致显著的发病率和死亡率。高特异性抗体是预防侵袭性疾病的主要保护机制。用于评估疫苗且能准确比较临床研究数据的、稳健且标准化的功能性抗体检测方法也是必要的。本综述简述了功能性抗体检测方法的现状及其在衡量保护性免疫方面的重要性。
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