Fenaux P, Jouet J P, Delerive C, Simon M, Pollet J P, Savinel P, Fabri M C, Ciesla I, Gosselin B, Bauters F
Service des maladies du sang, CHU, Lille.
Rev Med Interne. 1988 Mar-Apr;9(2):149-52. doi: 10.1016/s0248-8663(88)80114-0.
Two male patients, aged 36 and 73 years respectively, gradually developed febrile pancytopenia with profound alteration of their general condition and major inflammatory repercussions. No superficial or deep lymph node enlargement was found initially. Patient n degree 2 had an enlarged spleen. In both cases histological examination of the bone marrow showed an extensive and apparently nonspecific myelofibrosis. The subsequent development of superficial lymphadenopathy provided a firm diagnosis of Hodgkin's disease with mixed cellularity. These two cases belong to the category of exceptional massive medullary forms of Hodgkin's disease described by Duhamel et al. in 1979.
两名男性患者，年龄分别为36岁和73岁，逐渐出现发热性全血细胞减少，全身状况严重改变并伴有严重的炎症反应。最初未发现浅表或深部淋巴结肿大。2度患者脾脏肿大。在这两个病例中，骨髓组织学检查均显示广泛且明显非特异性的骨髓纤维化。随后出现的浅表淋巴结病确诊为混合细胞型霍奇金病。这两个病例属于Duhamel等人于1979年描述的霍奇金病特殊的大量髓质型。
