Previtera Francesca, Restaino Stefano, Romano Giulio, Vizzielli Giuseppe, Neri Andrea, Scalzotto Elisa, Vetrugno Luigi, Montessoro Beatrice, Mioni Roberto, Driul Lorenza
Obstetrics and Gynecology Unit, Department of Obstetrics Gynecology and Pediatrics, Udine University Hospital, DAME, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Dialysis and Transplantation Unit, Department of Nephrology, Udine University Hospital, DAME, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy.
Healthcare (Basel). 2021 Jun 28;9(7):821. doi: 10.3390/healthcare9070821.
Pregnancy can be considered as an allogeneic transplant and preeclampsia can be seen as a failure of the acceptance mechanisms of this transplant as occurs in acute organ transplant rejection. Some genetic polymorphisms may be involved in its pathogenesis. Since the kidney is one of the organs mainly involved in preeclampsia, our study attempted to determine the frequencies of single nucleotide polymorphisms of DNA (SNP) in 3 genes (adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1)/multi drug reactivity 1 (MDR1) gene, interleukin 10 gene and tumor necrosis factor α gene) which are targets of immunosuppressive therapies and related to acute renal rejection. The study was an observational, monocentric, case-control study. We enrolled 20 women with severe preeclampsia and 10 women age-matched with regular pregnancy. Continuous variables were compared by the Student's -test for independent variables or using the Mann-Whitney test depending on their distribution. We used Fisher test to compare categorical variables between cases and controls, while we used logistic regression model to evaluate which risk factor was associated with preeclampsia. Although there was no statistically significant difference between the two groups, we found different percentages of two of the polymorphisms considered (rs1045642 and rs2032582 in the gene ABCB1). Despite these results, our work may be helpful for future research to better understand the pathogenesis of preeclampsia.
妊娠可被视为一种同种异体移植，而子痫前期可被看作是这种移植的免疫耐受机制出现故障，类似于急性器官移植排斥反应。一些基因多态性可能参与其发病机制。由于肾脏是子痫前期主要累及的器官之一，我们的研究试图确定3个基因（三磷酸腺苷结合盒转运体B亚家族成员1（ABCB1）/多药耐药性1（MDR1）基因、白细胞介素10基因和肿瘤坏死因子α基因）的单核苷酸多态性（SNP）频率，这些基因是免疫抑制治疗的靶点且与急性肾排斥反应相关。该研究是一项观察性、单中心病例对照研究。我们纳入了20名单纯性重度子痫前期患者和10名年龄匹配的正常妊娠女性。连续变量根据其分布情况，采用独立样本t检验或Mann-Whitney检验进行比较。我们使用Fisher检验比较病例组和对照组之间的分类变量，同时使用逻辑回归模型评估哪些危险因素与子痫前期相关。尽管两组之间没有统计学上的显著差异，但我们发现所研究的两种多态性（ABCB1基因中的rs1045642和rs2032582）的比例有所不同。尽管有这些结果，我们的工作可能有助于未来更好地理解子痫前期发病机制的研究。
