McGowan J D, Altman R E, Kanto W P
Department of Pediatrics, Medical College of Georgia, Augusta 30912.
South Med J. 1988 Sep;81(9):1092-4. doi: 10.1097/00007611-198809000-00006.
We have identified eight infants born to mothers who were heavy users of caffeine during pregnancy. These infants exhibited unusual behavior in the immediate newborn period. Predominant symptoms were irritability, jitteriness, and vomiting. The eight infants had extensive diagnostic studies and none of the usual causes for their symptoms were identified. Caffeine was present in the serum of six infants, and three of the six infants had caffeine in their urine. The symptoms resolved spontaneously. We hypothesize that these infants were exposed to high maternal levels of caffeine for the majority of the pregnancy, resulting in a withdrawal syndrome after delivery.
我们已经确定了八名母亲在孕期大量摄入咖啡因的婴儿。这些婴儿在新生儿早期表现出异常行为。主要症状为易怒、颤抖和呕吐。这八名婴儿接受了广泛的诊断检查，但未发现导致其症状的常见原因。六名婴儿的血清中含有咖啡因，其中三名婴儿的尿液中也含有咖啡因。症状自行缓解。我们推测，这些婴儿在孕期的大部分时间里接触到了高水平的母体咖啡因，导致出生后出现戒断综合征。
