Ford R P, Schluter P J, Mitchell E A, Taylor B J, Scragg R, Stewart A W
Community Paediatric Unit, Community Child and Family Service, Christchurch, New Zealand.
Arch Dis Child. 1998 Jan;78(1):9-13. doi: 10.1136/adc.78.1.9.
To examine the association between maternal caffeine consumption during pregnancy and the risk of sudden infant death syndrome (SIDS).
A nationwide case-control study surveying parents of 393 SIDS victims and parents of 1592 control infants. Caffeine consumption in each of the first and third trimesters was estimated by questionnaire. Heavy caffeine intake was defined as 400 mg/day or more (equivalent to four or more cups of coffee per day).
Infants whose mothers had heavy caffeine consumption throughout their pregnancy had a significantly increased risk for SIDS (odds ratio 1.65; 95% confidence interval 1.15 to 2.35) after adjusting for likely confounding factors.
Caffeine intake has been associated with fetal harm and now SIDS. Reducing heavy caffeine intake during pregnancy could be another way to lessen the risk of SIDS. This needs confirmation by others.
研究孕期母亲咖啡因摄入量与婴儿猝死综合征（SIDS）风险之间的关联。
一项全国性病例对照研究，调查了393名SIDS受害者的父母和1592名对照婴儿的父母。通过问卷调查估计孕早期和孕晚期的咖啡因摄入量。高咖啡因摄入量定义为每天400毫克或更多（相当于每天四杯或更多咖啡）。
在调整可能的混杂因素后，母亲在整个孕期摄入大量咖啡因的婴儿患SIDS的风险显著增加（比值比1.65；9%置信区间1.15至2.35）。
咖啡因摄入与胎儿伤害有关，现在又与SIDS有关。孕期减少高咖啡因摄入量可能是降低SIDS风险的另一种方法。这需要其他人进行证实。
