Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Viruses. 2021 Jun 3;13(6):1057. doi: 10.3390/v13061057.
The isolation and characterization of bacteriophages for the treatment of infections caused by the multidrug resistant pathogen is imperative as nosocomial and community-acquired infections are rapidly increasing in prevalence. This increase is largely due to the numerous virulence factors and antimicrobial resistance genes encoded by this bacterium. Research on phages to date has focused on the isolation and in vitro characterization of novel phages, often including genomic characterization, from the environment or by induction from bacterial strains. This review summarizes the clinical significance, virulence factors, and antimicrobial resistance mechanisms of , as well as all phages isolated and characterized to date and strategies for their use. We further address the limited in vivo phage therapy studies conducted against this bacterium and discuss the future research needed to spearhead phages as an alternative treatment option against multidrug resistant .
由于医院内和社区获得性感染的迅速增加，迫切需要分离和鉴定能够治疗多药耐药病原体引起的感染的噬菌体。这种增加在很大程度上是由于该细菌编码的许多毒力因子和抗微生物耐药基因。迄今为止，噬菌体的研究主要集中在从环境中分离和体外鉴定新型噬菌体，通常包括基因组特征，或通过从细菌菌株诱导来进行。本综述总结了 的临床意义、毒力因子和抗微生物耐药机制，以及迄今为止分离和鉴定的所有噬菌体及其应用策略。我们进一步讨论了针对该细菌进行的有限的体内噬菌体治疗研究，并讨论了需要开展哪些未来研究，以推动噬菌体作为多药耐药 的替代治疗选择。
