Chiedozi L C
Department of Surgery, College of Medical Sciences, University of Benin, Nigeria, West Africa.
Surg Gynecol Obstet. 1988 Oct;167(4):303-6.
The clinical presentation and survival rate for 30 patients with Stage IV carcinoma of the breast in whom the M1 disease was limited exclusively to the bones were compared with those of 30 women with stage, age and menopausally matched carcinoma of the breast with M1 disease limited exclusively to nonosseous tissue. The clinical findings at presentation and the histologic grades of the cancers (70.0 per cent grade II for osseous versus only 36.7 per cent for nonosseous), relative to the mean duration of tumor presence, identify the cancer with exclusive skeletal metastases as less aggressive. Also, the median survival time of the patients with bone-only metastases was 12 months as compared with six months for the nonosseous metastatic group. It is concluded that exclusive skeletal metastases identify more slowly growing carcinoma of the breast and is, therefore, prognostically significant.
对30例IV期乳腺癌患者（其M1期疾病仅局限于骨骼）的临床表现和生存率，与30例年龄、分期和绝经状态相匹配的乳腺癌女性患者进行了比较，后一组患者的M1期疾病仅局限于非骨组织。就诊时的临床发现以及癌症的组织学分级（骨转移患者中70.0%为II级，而非骨转移患者仅为36.7%），相对于肿瘤存在的平均持续时间，表明仅发生骨骼转移的癌症侵袭性较小。此外，仅发生骨转移的患者的中位生存时间为12个月，而非骨转移组为6个月。得出的结论是，仅发生骨骼转移表明乳腺癌生长较慢，因此在预后方面具有重要意义。
