Chan-Yeung M, Abboud R, Buncio A D, Vedal S
Department of Medicine, Vancouver General Hospital, Canada British, Columbia.
Thorax. 1988 Jun;43(6):462-6. doi: 10.1136/thx.43.6.462.
A six year follow up study of 750 aluminium smelter workers was undertaken to evaluate the relationship between the leucocyte count at the start of the study and the rate of decline in lung function. An inverse relationship between the leucocyte count and the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) was present cross sectionally irrespective of cigarette smoking habit. The initial leucocyte count was also significantly related to the mean annual decline in FEV1 in smokers (p = 0.04) but not in former smokers or those who had never smoked. These observations suggest that the leucocyte count is a factor influencing the annual decline in FEV1 in smokers.
对750名铝冶炼厂工人进行了一项为期六年的随访研究,以评估研究开始时的白细胞计数与肺功能下降速率之间的关系。无论吸烟习惯如何,白细胞计数与一秒用力呼气量(FEV1)和用力肺活量(FVC)之间均存在横断面的负相关关系。初始白细胞计数也与吸烟者FEV1的年平均下降显著相关(p = 0.04),但与既往吸烟者或从不吸烟者无关。这些观察结果表明,白细胞计数是影响吸烟者FEV1年下降的一个因素。