Agostini Simone, Mancuso Roberta, Costa Andrea S, Citterio Lorenzo A, Guerini Franca R, Meloni Mario, Navarro Jorge, Clerici Mario
IRCCS Fondazione Don Carlo Gnocchi ONLUS, 20148 Milan, Italy.
Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.
Vaccines (Basel). 2021 Jun 22;9(7):686. doi: 10.3390/vaccines9070686.
The etiology of Parkinson's disease (PD), a progressive nervous system disorder that affects movement, is still unknown; both genetic and environmental factor are believed to be involved in onset of the disease and its development. Herpes simplex virus type 1 (HSV-1), in particular, is suspected to have a role in PD. Paired Immunoglobulin-like type 2 receptor alpha (PILRA) is an inhibitory receptor that down-regulates inflammation and is expressed on innate immune cells. The rs1859788 polymorphism is protective against Alzheimer's disease, even in relation with HSV-1 antibody titers, but no data are available in PD. We analyzed HSV-1 antibody titers and rs1859788 in PD ( 51) and age-and sex-matched healthy controls (HC; 73). Results showed that HSV-1, but not cytomegalovirus (CMV) or human herpes virus type 6 (HHV-6) antibody titers were significantly higher in PD compared to HC ( = 0.045). The rs1859788 polymorphism was not differentially distributed between PD and HC, but the minor allele A was more frequently carried by PD (68%) compared to HC (50%) ( = 0.06). Notably, the rs1859788 minor allele A was statically more frequent in male PD (65%) compared to male HC (37%) ( = 0.036). Finally, no relation was found between HSV-1 antibody titers and genotype. Results herein suggest an involvement of HSV-1 in PD and indicate a possible interaction between gene polymorphisms and this neuropathology.
帕金森病（PD）是一种影响运动的进行性神经系统疾病，其病因仍不清楚；遗传和环境因素都被认为与该疾病的发病及其发展有关。特别是，1型单纯疱疹病毒（HSV-1）被怀疑在PD中起作用。配对免疫球蛋白样2型受体α（PILRA）是一种抑制性受体，可下调炎症反应，并在先天免疫细胞上表达。rs1859788多态性对阿尔茨海默病具有保护作用，甚至与HSV-1抗体滴度有关，但在PD中尚无相关数据。我们分析了51例PD患者和73例年龄及性别匹配的健康对照（HC）的HSV-1抗体滴度和rs1859788。结果显示，与HC相比，PD患者的HSV-1抗体滴度显著更高（P = 0.045），而巨细胞病毒（CMV）或6型人类疱疹病毒（HHV-6）抗体滴度则无显著差异。rs1859788多态性在PD和HC之间的分布没有差异，但与HC（50%）相比，PD患者携带次要等位基因A的频率更高（68%）（P = 0.06）。值得注意的是，与男性HC（37%）相比，男性PD患者中rs1859788次要等位基因A的频率在统计学上更高（65%）（P = 0.036）。最后，未发现HSV-1抗体滴度与基因型之间存在关联。本文结果提示HSV-1参与了PD，并表明基因多态性与这种神经病理学之间可能存在相互作用。
