Ahlswede Mareike, Nösel Patrick, Maudsley Andrew A, Sheriff Sulaiman, Mahmoudi Nima, Bronzlik Paul, Lanfermann Heinrich, Ding Xiao-Qi
Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Department of Radiology, University of Miami School of Medicine, Miami, FL 33136, USA.
Metabolites. 2021 Jun 9;11(6):371. doi: 10.3390/metabo11060371.
Aging effects on striato-thalamic metabolism in healthy human brains were studied in vivo using short-TE whole brain H-MR spectroscopic imaging (wbMRSI) on eighty healthy subjects aged evenly between 20 to 70 years at 3T. Relative concentrations of N-acetyl-aspartate (NAA), choline, total creatine (tCr), myo-inositol (mI), glutamate, and glutamine in bilateral caudate nucleus, putamen, pallidum, and thalamus were determined using signal normalization relative to brain tissue water. Linear regression analysis was used to analyze the age-dependence of the metabolite concentrations. The metabolite concentrations revealed spatial inhomogeneity across brain regions and metabolites. With age, NAA decreased significantly in bilateral caudate nucleus and putamen, left pallidum, and left thalamus, tCr decreased in left putamen and bilateral pallidum, mI increased in bilateral caudate nucleus and right thalamus, and spectral linewidth increased in left putamen and right thalamus. In conclusion, normal aging of striato-thalamic metabolism in healthy human is associated with regional specific decreases of NAA and tCr and increases of mI, which may reflect the individual role of each brain structure within brain functionality.
利用短回波时间全脑氢磁共振波谱成像（wbMRSI），在3T磁场下对80名年龄在20至70岁之间的健康受试者进行体内研究，以探讨衰老对健康人脑纹状体 - 丘脑代谢的影响。使用相对于脑组织水的信号归一化方法，测定双侧尾状核、壳核、苍白球和丘脑内N - 乙酰天门冬氨酸（NAA）、胆碱、总肌酸（tCr）、肌醇（mI）、谷氨酸和谷氨酰胺的相对浓度。采用线性回归分析来分析代谢物浓度与年龄的相关性。代谢物浓度显示出跨脑区和代谢物的空间不均匀性。随着年龄增长，双侧尾状核和壳核、左侧苍白球和左侧丘脑的NAA显著降低，左侧壳核和双侧苍白球的tCr降低，双侧尾状核和右侧丘脑的mI升高，左侧壳核和右侧丘脑的谱线宽度增加。总之，健康人纹状体 - 丘脑代谢的正常衰老与NAA和tCr的区域特异性降低以及mI的升高有关，这可能反映了每个脑结构在脑功能中的个体作用。
