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基于术中视频的胸段升主动脉双轴应变测量

Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta.

作者信息

Parikh Shaiv, Ganizada Berta, Debeij Gijs, Natour Ehsan, Maessen Jos, Spronck Bart, Schurgers Leon, Delhaas Tammo, Huberts Wouter, Bidar Elham, Reesink Koen

机构信息

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands.

Department of Cardiothoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.

出版信息

Biomedicines. 2021 Jun 11;9(6):670. doi: 10.3390/biomedicines9060670.

Abstract

Local biaxial deformation measurements are essential for the in-depth investigation of tissue properties and remodeling of the ascending thoracic aorta, particularly in aneurysm formation. Current clinical imaging modalities pose limitations around the resolution and tracking of anatomical markers. We evaluated a new intra-operative video-based method to assess local biaxial strains of the ascending thoracic aorta. In 30 patients undergoing open-chest surgery, we obtained repeated biaxial strain measurements, at low- and high-pressure conditions. Precision was very acceptable, with coefficients of variation for biaxial strains remaining below 20%. With our four-marker arrangement, we were able to detect significant local differences in the longitudinal strain as well as in circumferential strain. Overall, the magnitude of strains we obtained (range: 0.02-0.05) was in line with previous reports using other modalities. The proposed method enables the assessment of local aortic biaxial strains and may enable new, clinically informed mechanistic studies using biomechanical modeling as well as mechanobiological profiling.

摘要

局部双轴变形测量对于深入研究胸主动脉升部的组织特性和重塑,尤其是在动脉瘤形成方面至关重要。当前的临床成像方式在解剖标志物的分辨率和跟踪方面存在局限性。我们评估了一种基于术中视频的新方法,以评估胸主动脉升部的局部双轴应变。在30例接受开胸手术的患者中,我们在低压和高压条件下获得了重复的双轴应变测量值。精度非常可接受,双轴应变的变异系数保持在20%以下。通过我们的四标记排列,我们能够检测到纵向应变和周向应变的显著局部差异。总体而言,我们获得的应变幅度(范围:0.02 - 0.05)与先前使用其他方式的报告一致。所提出的方法能够评估局部主动脉双轴应变,并可能通过生物力学建模以及机械生物学分析实现新的、基于临床信息的机制研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e690/8230589/230cd400cdc5/biomedicines-09-00670-g001.jpg

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