Furue Masutaka, Furue Mihoko
Department of Dermatology, Kyushu University, Higashiku, Fukuoka 812-8582, Japan.
1-19-20 Momochi, Sawara-ku, Fukuoka 814-0006, Japan.
J Clin Med. 2021 Jun 11;10(12):2578. doi: 10.3390/jcm10122578.
OX40 is one of the co-stimulatory molecules expressed on T cells, and it is engaged by OX40L, primarily expressed on professional antigen-presenting cells such as dendritic cells. The OX40L-OX40 axis is involved in the sustained activation and expansion of effector T and effector memory T cells, but it is not active in naïve and resting memory T cells. Ligation of OX40 by OX40L accelerates both T helper 1 (Th1) and T helper 2 (Th2) effector cell differentiation. Recent therapeutic success in clinical trials highlights the importance of the OX40L-OX40 axis as a promising target for the treatment of atopic dermatitis.
OX40是一种在T细胞上表达的共刺激分子，它与主要在专业抗原呈递细胞（如树突状细胞）上表达的OX40L结合。OX40L-OX40轴参与效应T细胞和效应记忆T细胞的持续激活和扩增，但在初始和静止记忆T细胞中不活跃。OX40L与OX40的结合加速了辅助性T细胞1（Th1）和辅助性T细胞2（Th2）效应细胞的分化。近期临床试验中的治疗成功突出了OX40L-OX40轴作为特应性皮炎治疗的一个有前景靶点的重要性。
