Forni Cinzia, Rossi Massimiliano, Borromeo Ilaria, Feriotto Giordana, Platamone Giovambattista, Tabolacci Claudio, Mischiati Carlo, Beninati Simone
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
PhD Program in Evolutionary Biology and Ecology, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Molecules. 2021 Jun 11;26(12):3583. doi: 10.3390/molecules26123583.
Nutraceuticals are biologically active molecules present in foods; they can have beneficial effects on health, but they are not available in large enough quantities to perform this function. Plant metabolites, such as polyphenols, are widely diffused in the plant kingdom, where they play fundamental roles in plant development and interactions with the environment. Among these, flavonoids are of particular interest as they have significant effects on human health. In vitro and/or in vivo studies described flavonoids as essential nutrients for preventing several diseases. They display broad and promising bioactivities to fight cancer, inflammation, bacterial infections, as well as to reduce the severity of neurodegenerative and cardiovascular diseases or diabetes. Therefore, it is not surprising that interest in flavonoids has sharply increased in recent years. More than 23,000 scientific publications on flavonoids have described the potential anticancer activity of these natural molecules in the last decade. Studies, in vitro and in vivo, show that flavonoids exhibit anticancer properties, and many epidemiological studies confirm that dietary intake of flavonoids leads to a reduced risk of cancer. This review provides a glimpse of the mechanisms of action of flavonoids on cancer cells.
营养保健品是食物中存在的生物活性分子；它们对健康有益，但数量不足以发挥此功能。植物代谢产物，如多酚，在植物界广泛分布，它们在植物发育和与环境的相互作用中发挥着重要作用。其中，黄酮类化合物特别受关注，因为它们对人类健康有显著影响。体外和/或体内研究将黄酮类化合物描述为预防多种疾病的必需营养素。它们具有广泛且有前景的生物活性，可对抗癌症、炎症、细菌感染，还能减轻神经退行性疾病、心血管疾病或糖尿病的严重程度。因此，近年来对黄酮类化合物的兴趣急剧增加也就不足为奇了。在过去十年中，超过23000篇关于黄酮类化合物的科学出版物描述了这些天然分子的潜在抗癌活性。体外和体内研究表明，黄酮类化合物具有抗癌特性，许多流行病学研究证实，饮食中摄入黄酮类化合物可降低患癌风险。本综述简要介绍了黄酮类化合物对癌细胞的作用机制。
