Zhang Zhijun, Shi Jian, Yang Tao, Liu Tongjun, Zhang Kai
Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130012, P.R. China.
Oncol Lett. 2021 Jan;21(1):43. doi: 10.3892/ol.2020.12304. Epub 2020 Nov 17.
Aggressive fibromatosis or desmoid tumor is a rare disease resulting from fibroblasts which do not metastasize. However, desmoid tumors belong to low-grade malignant tumors since they have high potential to infiltrate surrounding tissues, causing high local recurrence rates and may affect surrounding organs, threatening life quality and expectancy. Although surgery, watch and wait, radiotherapy, chemotherapy, high intensity focused ultrasound, ablation techniques or several agents have all been frequently investigated for the treatment of this type of disease, none are deemed as standard therapy for high recurrence rates that have been supported by any data. The present review retrieved literature on treatment options for desmoids to summarize the latest treatment modalities and refine their efficacy, as well as their side effects, in order to provide a more comprehensive treatment reference for clinicians.
侵袭性纤维瘤病或韧带样瘤是一种由不发生转移的成纤维细胞引起的罕见疾病。然而，韧带样瘤属于低度恶性肿瘤，因为它们具有很高的浸润周围组织的潜力，导致局部复发率高，并且可能影响周围器官，威胁生活质量和预期寿命。尽管手术、观察等待、放疗、化疗、高强度聚焦超声、消融技术或几种药物都经常被研究用于治疗这类疾病，但由于高复发率，没有一种被视为有任何数据支持的标准疗法。本综述检索了关于韧带样瘤治疗选择的文献，以总结最新的治疗方式，并细化其疗效以及副作用，以便为临床医生提供更全面的治疗参考。
