Lillo Eugenia, Gutierrez-Cardo Antonio, Murcia-Casas Belén, Carrillo-Linares Juan Luis, Garcia-Argüello Francisco, Chicharo de Freitas Reinaldo, Baquero-Aranda Isabel, Valdivielso Pedro, García-Fernández María, Sánchez-Chaparro Miguel Ángel
Molecular Imaging Unit, Centro de Investigaciones Médico Sanitarias (CIMES), Fundación General de la Universidad de Málaga, 29010 Málaga, Spain.
Nuclear Medicine Department, Regional Hospital, 29010 Malaga, Spain.
J Clin Med. 2021 Jun 11;10(12):2588. doi: 10.3390/jcm10122588.
Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease.
弹性纤维的活性微钙化是弹性假黄瘤的一个标志，可通过使用PET/CT扫描评估皮肤和血管水平的18F-NaF沉积来进行测量。在没有特定治疗的情况下，这种沉积是否会随时间变化尚不清楚。我们在两年内对患有该疾病的患者重复进行了使用18F-NaF作为放射性药物的PET/CT扫描，并比较了皮肤和血管处的沉积情况。此外，还评估了血管壁的钙评分值。主要结果表明，在血管壁中，每位患者的钙化都有所进展；相比之下，测量的活性微钙化和靶本比显示活性沉积减少。相比之下，在皮肤水平（颈部和腋窝），药物摄取保持不变。总之，由于动脉壁钙化并非弹性假黄瘤所特有，因此在颈部测量18F-NaF的沉积可能在未来该疾病的试验中用作替代标志物。
