Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, No. 486, South Karegar Ave., Tehran 1336616357, Iran.
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
J Subst Abuse Treat. 2022 Mar;134:108555. doi: 10.1016/j.jsat.2021.108555. Epub 2021 Jun 24.
Several factors may influence the validity of self-report. In this study, we aimed to assess the validity of self-reported drug use compared to urine testing among treatment-seeking patients with opioid use disorder (OUD).
This cross-sectional study recruited 293 patients with OUD, referred to the Iranian National Center for Addiction Studies (INCAS) clinic, from November 2015 to June 2017. The study compared self-reported opioid use in the past 72 h with the results of urinalysis, using immunoassay technique. We estimated sensitivity, negative predictive value, percent agreement, positive percent agreement, and Cohen's kappa statistics for those with OUD.
The sensitivity of self-reported opioid use was 85.9%. Percent agreement, positive percent agreement, and Cohen's Kappa statistics between self-reported opioid use and urine testing for morphine in the first month were 88.5%, 78.1%, and 77.0, respectively. Multilevel logistic regression showed that longer treatment duration (OR = 1.21, 95%CI: 1.07-1.37, p-value = 0.002) was significantly associated with the agreement of self-reported opioid use with urine testing.
Self-report can be used as a reliable method for monitoring treatment adherence combined with random urine tests.
有几个因素可能会影响自我报告的有效性。在这项研究中，我们旨在评估与接受治疗的阿片类药物使用障碍（OUD）患者的尿液检测相比，自我报告的药物使用的有效性。
这项横断面研究于 2015 年 11 月至 2017 年 6 月招募了 293 名来自伊朗国家成瘾研究中心（INCAS）诊所的 OUD 患者。该研究使用免疫测定技术比较了过去 72 小时内自我报告的阿片类药物使用情况与尿液分析结果。我们对那些患有 OUD 的患者估计了敏感性、阴性预测值、百分比一致性、阳性百分比一致性和 Cohen's kappa 统计量。
自我报告的阿片类药物使用的敏感性为 85.9%。在第一个月，自我报告的阿片类药物使用和尿液检测吗啡的百分比一致性、阳性百分比一致性和 Cohen's Kappa 统计量分别为 88.5%、78.1%和 77.0%。多水平逻辑回归显示，治疗时间延长（OR=1.21，95%CI：1.07-1.37，p 值=0.002）与自我报告的阿片类药物使用与尿液检测的一致性显著相关。
自我报告可以与随机尿液检测结合使用，作为监测治疗依从性的可靠方法。
