Sameed Muhammad, Choi Humberto, Auron Moises, Mireles-Cabodevila Eduardo
Department of Pulmonary & Critical Care, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
Respir Care. 2021 Jul;66(7):1150-1166. doi: 10.4187/respcare.09154.
Postoperative pulmonary complications have a significant impact on perioperative morbidity and mortality and contribute substantially to health care costs. Surgical stress and anesthesia lead to changes in respiratory physiology, altering lung volumes, respiratory drive, and muscle function that can cumulatively increase the risk of postoperative pulmonary complications. Preoperative medical evaluation requires a structured approach to identify patient-, procedure-, and anesthesia-related risk factors for postoperative pulmonary complications. Validated risk prediction models can be used for risk stratification and to help tailor the preoperative investigation. Optimization of pulmonary comorbidities, smoking cessation, and correction of anemia are risk-mitigation strategies. Lung-protective ventilation, moderate PEEP application, and conservative use of neuromuscular blocking drugs are intra-operative preventive strategies. Postoperative early mobilization, chest physiotherapy, oral care, and appropriate analgesia speed up recovery. High-risk patients should receive inspiratory muscle training prior to surgery, and there should be a focus to minimize surgery time.
术后肺部并发症对围手术期的发病率和死亡率有重大影响,并在很大程度上增加了医疗成本。手术应激和麻醉会导致呼吸生理的改变,改变肺容量、呼吸驱动力和肌肉功能,这些变化会累积增加术后肺部并发症的风险。术前医学评估需要采用结构化方法,以识别与患者、手术和麻醉相关的术后肺部并发症风险因素。经过验证的风险预测模型可用于风险分层,并有助于调整术前检查。优化肺部合并症、戒烟和纠正贫血是降低风险的策略。肺保护性通气、适度应用呼气末正压通气(PEEP)以及谨慎使用神经肌肉阻滞药物是术中预防策略。术后早期活动、胸部物理治疗、口腔护理和适当的镇痛可加速康复。高危患者应在手术前接受吸气肌训练,并且应注重尽量缩短手术时间。