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Reengineering protein-phosphorylation switches.

作者信息

Kholodenko Boris N, Okada Mariko

机构信息

Systems Biology Ireland, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.

出版信息

Science. 2021 Jul 2;373(6550):25-26. doi: 10.1126/science.abj5028.

DOI:10.1126/science.abj5028
PMID:34210865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8327301/
Abstract
摘要

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Elife. 2020 Jul 24;9:e58165. doi: 10.7554/eLife.58165.
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De novo design of protein logic gates.从头设计蛋白质逻辑门。
Science. 2020 Apr 3;368(6486):78-84. doi: 10.1126/science.aay2790.
3
Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction.逻辑门控 DNA 控制的受体组装用于细胞信号转导的可编程调节。
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Balancing a genetic toggle switch by real-time feedback control and periodic forcing.通过实时反馈控制和周期性强制实现遗传切换开关的平衡。
Nat Commun. 2017 Nov 17;8(1):1671. doi: 10.1038/s41467-017-01498-0.
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Two Bistable Switches Govern M Phase Entry.两个双稳态开关控制M期进入。
Curr Biol. 2016 Dec 19;26(24):3361-3367. doi: 10.1016/j.cub.2016.10.022. Epub 2016 Nov 23.
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Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.运用光遗传学技术探究 Ras/Erk 模块对信号传递的动态调控。
Cell. 2013 Dec 5;155(6):1422-34. doi: 10.1016/j.cell.2013.11.004.
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Systems biology of stem cell fate and cellular reprogramming.干细胞命运与细胞重编程的系统生物学
Nat Rev Mol Cell Biol. 2009 Oct;10(10):672-81. doi: 10.1038/nrm2766. Epub 2009 Sep 9.
8
Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle.开关转换、脉冲和振荡是Src激活/失活循环的固有特性。
FEBS J. 2009 Aug;276(15):4102-18. doi: 10.1111/j.1742-4658.2009.07117.x.
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A tunable synthetic mammalian oscillator.一种可调谐的合成哺乳动物振荡器。
Nature. 2009 Jan 15;457(7227):309-12. doi: 10.1038/nature07616.
10
A bistable Rb-E2F switch underlies the restriction point.一种双稳态的Rb-E2F开关构成了限制点的基础。
Nat Cell Biol. 2008 Apr;10(4):476-82. doi: 10.1038/ncb1711. Epub 2008 Mar 23.