Iberahim Salfarina, Noor Noor Haslina Mohd, Hassan Mohd Nazri, Bahar Rosnah, Yusoff Shafini Mohdmed, Ramli Marini, Abdul Rahman Wan Suriana Wan, Zulkafli Zefarina, Abdullah Marne, Fong Ho Sook, Mohamed Shihabudin Tengku Muzafar Tengku, Edinur Hisham Atan, Che Ghazali Norul Hajar
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Transfusion Medicine Unit, Hospital Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Asian J Transfus Sci. 2022 Jul-Dec;16(2):276-279. doi: 10.4103/ajts.ajts_136_21. Epub 2022 Nov 12.
The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations.
迭戈（Di）血型系统由位于带3蛋白上的22种抗原组成，其中大多数是低频率抗原。针对迭戈系统抗原的大多数抗体在临床上无显著意义；然而，抗Dia、-Dib、-Wra、-ELO和-DISK可能会导致胎儿和新生儿溶血病（HDFN）以及输血反应。我们报告了一例年轻男性自然产生抗Dia的病例，该男性因手指受伤到我院进行伤口清创。他的血清学结果提示存在抗Dia抗体，其分子血型显示他具有Di（a-b+）抗原。抗Dia可能具有临床意义。它可导致轻度至重度的HDFN，但仅有罕见报道表明其与溶血性输血反应有明确关联。我们建议在针对我们人群的抗体鉴定试验中，试剂红细胞面板应包含Dia抗原阳性细胞。
