Fu Xiaolong, Wan Peifeng, Li Peipei, Wang Jinpeng, Guo Siwei, Zhang Yuan, An Yachun, Ye Chao, Liu Ziyi, Gao Jiangang, Yang Jianming, Fan Jiangang, Chai Renjie
State Key Laboratory of Bioelectronics, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, School of Life Sciences and Technology, Southeast University, Nanjing, China.
School of Life Science, Shandong University, Qingdao, China.
Front Cell Neurosci. 2021 Jun 15;15:692762. doi: 10.3389/fncel.2021.692762. eCollection 2021.
Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems. In this article, we mainly introduce the main mechanism of ototoxicity induced by aminoglycosides. Genetic analysis showed that the susceptibility of aminoglycosides was attributable to mutations in mtDNA, especially A1555G and C1494T mutations in 12S rRNA. In addition, the overexpression of NMDA receptors and the formation of free radicals also play an important role. Understanding the mechanism of ototoxicity induced by aminoglycosides is helpful to develop new therapeutic methods to protect hearing. In this article, the prevention methods of ototoxicity induced by aminoglycosides were introduced from the upstream and downstream aspects.
氨基糖苷类药物是一类具有重要临床意义的药物，在全球范围内广泛用于治疗革兰氏阴性菌感染。然而，越来越多的证据表明，氨基糖苷类药物会导致听力丧失或平衡问题。在本文中，我们主要介绍氨基糖苷类药物引起耳毒性的主要机制。基因分析表明，氨基糖苷类药物的易感性归因于线粒体DNA（mtDNA）的突变，尤其是12S rRNA中的A1555G和C1494T突变。此外，N-甲基-D-天冬氨酸（NMDA）受体的过度表达和自由基的形成也起重要作用。了解氨基糖苷类药物引起耳毒性的机制有助于开发保护听力的新治疗方法。本文从上游和下游方面介绍了氨基糖苷类药物耳毒性的预防方法。
