镰状细胞病患者的腿部溃疡

Granja Paula Dadalti, Quintão Samuel Braulio Magalhães, Perondi Franciele, de Lima Rosemary Bacellar Ferreira, Martins Cláudia Labriola de Medeiros, Marques Marcos Arêas, de Oliveira Julio Cesar Peclat

Departamento de Medicina Clínica - MMC, Faculdade de Medicina, Universidade Federal Fluminense - UFF, Niterói, RJ, Brasil.

Hospital Universitário Antônio Pedro - HUAP, Niterói, RJ, Brasil.

J Vasc Bras. 2020 Nov 11;19:e20200054. doi: 10.1590/1677-5449.200054.

Leg ulcers are the most common cutaneous complication of sickle cell disease. These lesions occur mainly in homozygous forms, are slow to heal and often relapse, causing negative physical, emotional, and economic impacts. In this paper, we discuss the clinical presentation, diagnosis, and pathophysiology of sickle cell leg ulcers and their implications for treatment.

腿部溃疡是镰状细胞病最常见的皮肤并发症。这些病变主要发生在纯合子形式中，愈合缓慢且常复发，会对身体、心理和经济造成负面影响。在本文中，我们讨论镰状细胞性腿部溃疡的临床表现、诊断、病理生理学及其对治疗的影响。