综述：腿部溃疡——镰状细胞病的一种继发性并发症。
Mini review: leg ulcers - a secondary complication of sickle cell disease.
作者信息
AlDallal Salma M
机构信息
Haematology & Blood Bank Department, Amiri Hospital, Kuwait Ministry of Health, Sharq, Kuwait.
出版信息
Int J Gen Med. 2019 Aug 13;12:279-282. doi: 10.2147/IJGM.S217369. eCollection 2019.
Abstract
Sickle cell disease (SCD) is a group of inherited blood disorders recognized by WHO as a major public health problem. It affects morbidity and mortality of the affected population considerably. Leg ulcer in the lower limbs is a hallmark feature of SCD. Meticulous physical examination, thorough history, laboratory tests, and imaging will lead to proper diagnosis and lead to proper treatment and management of the cases. Although newer treatment strategies have improved the prognostic outcome of SCD, leg ulcers still are a disabling and difficult to treat a complication of the condition. This mini review summarizes this common complication of SCD.
摘要
镰状细胞病（SCD）是一组遗传性血液疾病，被世界卫生组织认定为一个重大的公共卫生问题。它对受影响人群的发病率和死亡率有相当大的影响。下肢腿部溃疡是镰状细胞病的一个标志性特征。细致的体格检查、详尽的病史询问、实验室检查以及影像学检查将有助于做出正确诊断，并对病例进行恰当的治疗和管理。尽管新的治疗策略改善了镰状细胞病的预后，但腿部溃疡仍然是该病症一种致残且难以治疗的并发症。本综述总结了镰状细胞病的这一常见并发症。
相似文献
1
Mini review: leg ulcers - a secondary complication of sickle cell disease.综述：腿部溃疡——镰状细胞病的一种继发性并发症。
Int J Gen Med. 2019 Aug 13;12:279-282. doi: 10.2147/IJGM.S217369. eCollection 2019.
2
Sickle cell leg ulcers: a frequently disabling complication and a marker of severity.镰状细胞性腿部溃疡：一种常见的致残性并发症及严重程度的标志。
Br J Dermatol. 2008 Feb;158(2):339-44. doi: 10.1111/j.1365-2133.2007.08323.x. Epub 2007 Nov 28.
3
Prevalence and Predictive Factors for Leg Ulcers in Sickle Cell Disease Patients in Saudi Arabia: A Cross-Sectional Observational Study.沙特阿拉伯镰状细胞病患者腿部溃疡的患病率及预测因素：一项横断面观察性研究
Cureus. 2020 Oct 31;12(10):e11280. doi: 10.7759/cureus.11280.
4
Successful Management of a Chronic Refractory Leg Ulcer in an Adolescent with Sickle Cell Anemia.镰状细胞贫血青少年慢性难治性腿部溃疡的成功管理
Acta Dermatovenerol Croat. 2015;23(3):213-7.
5
Cutaneous adverse reactions to hydroxyurea in patients with sickle cell disease.镰状细胞病患者对羟基脲的皮肤不良反应。
Arch Dermatol. 2001 Apr;137(4):467-70.
6
[Leg ulcers in sickle cell disease: A retrospective study of 40 cases].[镰状细胞病中的腿部溃疡：40例回顾性研究]
Ann Dermatol Venereol. 2016 Feb;143(2):103-7. doi: 10.1016/j.annder.2015.12.004. Epub 2016 Jan 12.
7
Healing of chronic sickle cell disease-associated foot and ankle wounds using transdermal continuous oxygen therapy.使用经皮持续氧疗治疗慢性镰状细胞病相关的足踝伤口。
J Wound Care. 2016 Feb;25(2):S23-4, S26-7. doi: 10.12968/jowc.2016.25.Sup2.S23.
8
Topical effectiveness of molgramostim (GM-CSF) in sickle cell leg ulcers.莫拉司亭（粒细胞-巨噬细胞集落刺激因子）治疗镰状细胞性腿部溃疡的局部疗效。
Dermatology. 2004;208(2):135-7. doi: 10.1159/000076487.
9
Critical Reviews: How we treat sickle cell patients with leg ulcers.Critical Reviews：我们如何治疗患有腿部溃疡的镰状细胞病患者。
Am J Hematol. 2016 Jan;91(1):22-30. doi: 10.1002/ajh.24134. Epub 2015 Aug 14.
10
SICKLE as a holistic treatment approach to sickle cell disease related ulcers.SICKLE：一种针对镰状细胞病相关溃疡的整体治疗方法。
Br J Nurs. 2018 Nov 8;27(20):S6-S10. doi: 10.12968/bjon.2018.27.Sup20.S6.
引用本文的文献
1
Adult Patients with HbS-Only Phenotype of Sickle Cell Disease Have a Decreased Arginine/Asymmetric Dimethylarginine Ratio.仅具有血红蛋白S（HbS）表型的镰状细胞病成年患者的精氨酸/不对称二甲基精氨酸比值降低。
Med Princ Pract. 2025 Apr 23:1-8. doi: 10.1159/000546047.
2
Leg Ulcers in Sickle Cell Disease: A Multifactorial Analysis Highlights the Hemolytic Profile.镰状细胞病中的腿部溃疡：多因素分析突出溶血特征
Hematol Rep. 2023 Feb 15;15(1):119-129. doi: 10.3390/hematolrep15010013.
3
Interventions for treating leg ulcers in people with sickle cell disease.治疗镰状细胞病患者腿部溃疡的干预措施。
Cochrane Database Syst Rev. 2021 Jan 9;1(1):CD008394. doi: 10.1002/14651858.CD008394.pub4.
4
Leg ulcers in sickle cell disease patients.镰状细胞病患者的腿部溃疡
J Vasc Bras. 2020 Nov 11;19:e20200054. doi: 10.1590/1677-5449.200054.
5
Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia.镰状细胞贫血患者中炎症分子、一氧化氮代谢产物与腿部溃疡之间的关联。
Hematol Transfus Cell Ther. 2022 Apr-Jun;44(2):169-176. doi: 10.1016/j.htct.2020.09.152. Epub 2020 Dec 5.
本文引用的文献
1
Evaluation of sociodemographic, clinical, and laboratory markers of sickle leg ulcers among young nigerians at a tertiary health institution.对一家三级医疗机构中年轻尼日利亚人镰状腿溃疡的社会人口统计学、临床和实验室指标的评估。
Niger J Clin Pract. 2018 Jul;21(7):882-887. doi: 10.4103/njcp.njcp_4_18.
2
Critical Reviews: How we treat sickle cell patients with leg ulcers.Critical Reviews：我们如何治疗患有腿部溃疡的镰状细胞病患者。
Am J Hematol. 2016 Jan;91(1):22-30. doi: 10.1002/ajh.24134. Epub 2015 Aug 14.
3
In vitro and in vivo anti-angiogenic effects of hydroxyurea.羟基脲的体外和体内抗血管生成作用。
Microvasc Res. 2014 Jul;94:106-13. doi: 10.1016/j.mvr.2014.05.009. Epub 2014 Jun 9.
4
Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign.沙特阿拉伯的镰状细胞病：具有阿拉伯-印度单倍型的成年人的表型并非良性。
Br J Haematol. 2014 Feb;164(4):597-604. doi: 10.1111/bjh.12650. Epub 2013 Nov 13.
5
Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcers.同型纯合镰状细胞病伴慢性腿部溃疡患者的血液黏度和炎症及黏附标志物的表达。
PLoS One. 2013 Jul 26;8(7):e68929. doi: 10.1371/journal.pone.0068929. Print 2013.
6
Sickle cell disease and leg ulcers.镰状细胞病和腿部溃疡。
Adv Skin Wound Care. 2012 Sep;25(9):420-8. doi: 10.1097/01.ASW.0000419408.37323.0c.
7
An adolescent with sickle cell anaemia experiencing disease-related complications: priapism and leg ulcer--a management challenge.一名患有镰状细胞贫血的青少年出现与疾病相关的并发症：阴茎异常勃起和腿部溃疡——管理挑战。
BMJ Case Rep. 2012 Apr 28;2012:bcr1120115146. doi: 10.1136/bcr.11.2011.5146.
8
Laboratory and echocardiography markers in sickle cell patients with leg ulcers.镰状细胞病患者下肢溃疡的实验室和超声心动图标志物。
Am J Hematol. 2011 Aug;86(8):705-8. doi: 10.1002/ajh.22065. Epub 2011 May 31.
9
Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia.牙买加的静脉功能不全、贫困和乳酸脱氢酶是镰状细胞贫血患者腿部溃疡的重要预测因素。
Br J Haematol. 2008 Jul;142(1):119-25. doi: 10.1111/j.1365-2141.2008.07115.x. Epub 2008 May 8.
10
Sickle cell disease.镰状细胞病
Pediatr Rev. 2007 Jul;28(7):259-68. doi: 10.1542/pir.28-7-259.
Zotero 插件