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在精原干细胞生成过程中，miR-302d与lncRNA-341竞争性结合靶向TLE4。

miR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation.

作者信息

Zhang Yani, Zhang Wenhui, Hu Cai, Wang Yingjie, Wang Man, Zuo Qisheng, Elsayed Ahmed Kamel, Li Yi, Li Bichun

机构信息

College of Animal Science and Technology, Yangzhou University, Jiangsu Province Key Laboratory of Animal Breeding and Molecular Design, Yangzhou, 225009 Jiangsu, China.

Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, 225009 Jiangsu, China.

出版信息

Stem Cells Int. 2021 Jun 8;2021:5546936. doi: 10.1155/2021/5546936. eCollection 2021.

DOI:10.1155/2021/5546936
PMID:34211555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8205581/
Abstract

MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.

摘要

微小RNA（miRNA）是家禽生殖过程中的重要因素。在此，我们发现miR-302d是鸡胚胎干细胞（ESC）向精原干细胞（SSC）分化的潜在负向因子。我们对竞争机制进行了初步探索，以确定miR-302d、lncRNA-341（与miR-302d相互作用）和靶基因TLE4之间的关系。结果表明，lncRNA-341可以竞争性结合miR-302d，减少miR-302d与TLE4的靶向结合，从而促进鸡精原干细胞的分化。此外，提示miR-302d可能通过TLE4参与Wnt信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c43/8205581/ec2bcd86b470/SCI2021-5546936.010.jpg
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