Caruana M P, Lahiri A, Cashman P M, Altman D G, Raftery E B
Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
Am J Cardiol. 1988 Oct 1;62(10 Pt 1):755-9. doi: 10.1016/0002-9149(88)91217-9.
In 20 subjects with chronic congestive heart failure due to coronary artery disease, the 24-hour variability of ambulatory intraarterial blood pressure (BP) was studied using an improved Oxford Medilog system, and correlated with left ventricular function at rest. The mean radionuclide ejection fraction was 27% (range 10 to 42), the mean pulmonary arterial wedge pressure was 18 mm Hg (5 to 37) and the mean cardiac index was 2.8 liters/min/m2 (2 to 3.8). The 24-hour systolic BP and heart rate (HR) variability indexes were less than those of 22 normal volunteers (p less than 0.05) and were strongly correlated (p less than 0.05) with ejection fraction at rest and pulmonary arterial wedge pressure. Stepwise regression showed that a combination of the mean nocturnal HR and the standard deviation of the hourly mean systolic BP values accounted for 67% of the variability in ejection fraction between patients. Similarly, 73% of the variation in pulmonary wedge pressure was explained by combining the 24-hour mean HR and the mean nocturnal HR.
在20例因冠状动脉疾病导致慢性充血性心力衰竭的患者中，使用改良的牛津Medilog系统研究了动态动脉内血压（BP）的24小时变异性，并将其与静息时的左心室功能进行了关联。平均放射性核素射血分数为27%（范围10%至42%），平均肺动脉楔压为18毫米汞柱（5至37），平均心脏指数为2.8升/分钟/平方米（2至3.8）。24小时收缩压和心率（HR）变异性指数低于22名正常志愿者（p<0.05），且与静息时的射血分数和肺动脉楔压密切相关（p<0.05）。逐步回归分析表明，夜间平均心率和每小时平均收缩压值的标准差相结合，可解释患者间射血分数变异性的67%。同样，24小时平均心率和夜间平均心率相结合，可解释肺楔压变化的73%。
