Cheng Xianzhong, Zhao Qian, Xu Xia, Guo Wenwen, Gu Hongyuan, Zhou Rui, Chen Chen, Ma Dawei, Wu Yinan, Ni Jing, Chen Xiaoxiang
Department of Gynecologic Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Department of Chemotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Front Oncol. 2021 Jun 11;11:672434. doi: 10.3389/fonc.2021.672434. eCollection 2021.
Yolk sac tumors (YSTs) of the endometrium and the broad ligament are very rare, with only 29 cases and one case of each other reported before in the English literature. Due to lack of standard guidelines, the treatment strategies of these diseases are controversial. Here, we share two cases of YSTs originating from the endometrium and the broad ligament respectively and review related literature. A 35-year-old woman was diagnosed with endometrial YST in our center and underwent surgery followed by chemotherapy with BEP (bleomycin, cisplatin and etoposide) regimen for six courses. After follow-up for 21 months, there is still no evidence of relapse. Another 36-year-old woman was admitted to our department with YST of the broad ligament. She was treated with surgery followed by chemotherapy with BEP regimen and was lost to follow-up after completing therapy. The case of endometrial YST we shared was similar to cases reported before, while the case with YST of the broad ligament we shared was the second case reported worldwide. Both of these two cases were treated with surgery combined with chemotherapy with BEP regimen.
子宫内膜和阔韧带卵黄囊瘤（YSTs）非常罕见，英文文献中此前分别仅报道过29例和1例。由于缺乏标准指南，这些疾病的治疗策略存在争议。在此，我们分享两例分别起源于子宫内膜和阔韧带的YSTs病例并回顾相关文献。一名35岁女性在我们中心被诊断为子宫内膜YST，接受了手术，随后采用博来霉素、顺铂和依托泊苷（BEP）方案进行了六个疗程的化疗。随访21个月后，仍无复发迹象。另一名36岁女性因阔韧带YST入住我科。她接受了手术，随后采用BEP方案化疗，完成治疗后失访。我们分享的子宫内膜YST病例与之前报道的病例相似，而我们分享的阔韧带YST病例是世界范围内报道的第二例。这两例均采用手术联合BEP方案化疗进行治疗。
